非小细胞肺癌_____](期刊论文)

血管内皮生长因子在非小细胞肺癌中的表达及意义

http://www.100md.com 《实用医技杂志》 2006年第2期

非小细胞肺癌,,],血管内皮生长因子；非小细胞肺癌；淋巴结转移,1材料与方法,2结果,3讨论,参考文献：

     [摘要] 目的：探讨非小细胞肺癌(NSCLC)中血管内皮生长因子(VEGF)表达与肿瘤浸润和淋巴结转移的关系。方法：应用VEGF抗体，采用微波LSAB免疫组化染色方法对78例手术切除的NSCLC进行VEGF免疫组化染色标记，并取10例正常组织对照。结果：78例NSCLC的VEGF平均为(65.8±14.3)，有淋巴结转移的VEGF(2.82±1.21)表达与无淋巴结转移的VEGF(1.28±1.08)、正常对照的VEGF(1.03±1.02)比较，差异具有非常显著的统计学意义(P<0.01)。VEGF与年龄、性别、吸烟史、肿瘤大小以及病理学分级等临床病理学特性均无明显相关关系(P>0.05)。结论：NSCLC内VEGF表达强度与淋巴结转移密切相关，可作为预测NSCLC病人预后和发生转移的生物学指标之一。

    [关键词] 血管内皮生长因子；非小细胞肺癌；淋巴结转移

    Expression of Vascular Endothelial Growth Factor in Human Nonsmall Cell Lung Carcinoma and its Significance

    ZHU Guangjun，XIONG Zhengwen，LI Hongwei，et al

    (The 322nd Hospital of PLA,Datong，Shanxi 037006，China；The 251st Hospital of PLA,Zhangjiakou,Hebei 075000,China)

    Abstract:Objective To investigate the relationship between the expression of vascular endothelial growth factor(VEGF) and lymph node metastasis of nonsmall cell lung carcinoma (NSCLC).Methods Immunohistochemical staining technique (LSAB method) using antibodies against VEGF was carried out on archival specimens of 78 cases of human NSCLC and 10 cases normal control.Results The average counts of VEGF in 78 NSCLC were 2.01+1.03.Expression of VEGF was higher in metastatic tumors(2.82±1.21) than in nonmetastatic tumors(1.28±1.08) and normal lung tissue(1.03±1.02). VEGF was related closed to lymph node metastasis(P<0.01).No relationship exist and patients' sex,age,history of smoking, the size of tumors, and histological type, etc.Conclusion The positive expression of VEGF is correlated with metastasis of non small cell lung cancer.VEGF may be used as a hopeful marker for predicting the prognosis and metastasis of patients with non small cell lung carcinoma. ......

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