甘草酸脂质体的处方及制备工艺
甘草酸,,甘草酸;脂质体;均匀设计法;包封率,0引言,1材料和方法,2结果,3讨论,【参考文献】
Formulation and preparation of glycyrrhizic acid liposomeCHENG JianFeng, HU BenQuan, LIU Mei, HE JianRong,YANG Sheng, WANG BiShi
Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xian 710038,China
【Abstract】 AIM: To optimize the prescription and preparation of encapsulated liposome. METHODS: The liposomes were prepared by conventional rotaryevaporated filmultrasonication method. The prescription and preparation of liposome were optimized by uniform design. Its shape and size distribution were detected under transmission electron microscope. A method to determine the encapsulated rate of the liposome by high performance liquid (HPLC) was established. RESULTS: Glycyrrhizic acid liposome was regular under its microphotograph and the diameter was 40-60 nm. The entrapment efficiency of the glycyrrhizic acid liposome was 63.0%-89.0%. CONCLUSION: The entrapment efficiency of glycyrrhizic acid liposome and the stability of glycyrrhizic acid liposome prepared by conventional rotaryevaporated filmultrasonication method is good. ......
您现在查看是摘要页,全文长 5834 字符。