活血化瘀中药治疗原发性肝癌研究进展
肝肿瘤,,],肝肿瘤;,活血祛瘀;,中草药,1中医对肝癌血瘀证的认识,2活血化瘀中药在原发性肝癌治疗中的应用,3活血化瘀中药治疗原发性肝癌的作用机制,4问题与
[关键词] 肝肿瘤; 活血祛瘀; 中草药Progress in research on the treatment of primary liver cancer with traditional Chinese medicine for activating blood to resolve stasis
JU LiXia, CHEN Zhe, REN RongZheng
(Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; Department of Haematology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China)
KEY WORDS liver neoplasms; activating blood to resolve stasis; drug, Chinese herbal
1 中医对肝癌血瘀证的认识
中医学中没有原发性肝癌病名,根据其临床症状及病因病机属于“积聚”、“肝积”、“鼓胀”、“胁痛”等范畴,认为由于寒邪、湿热及虚邪等侵袭人体,加之饮食不洁,损伤脾胃;或情志郁结,气滞血瘀而结成积。如《内经》载有:“血气稽留不得行,故宿昔而成积矣。”宋代《圣济总录》云:“瘤之为义,留置而不去也,气血流行不失其常,则形体平和,或余赘及郁结壅塞,则乘应投隙,瘤所以生。”唐容川的《血证论》中载:“淤血在经络、脏腑之间,结为癥瘕。”王清任在《医林改错》中指出:“肚腹结块,必有形之血也,血受寒则凝结成块,血受热则煎熬成块。”可见血瘀是肝癌的重要病理基础及临床表现。故临床上活血化瘀成为肝癌治疗中的重要方法。
传统医学中对活血化瘀法治疗原发性肝癌的记载很多,如《素问·阴阳应象大论》中就记载了:“血实宜决之,气虚宜掣引之。”《素问·针解篇》更明确指出:“菀陈则除之者,出恶血也。”《神农本草经》记录了丹参“破癥除瘕”,牡丹皮“除癥坚瘀血”,桃仁“治瘀血、血闭、癥瘕邪气”,水蛭“主逐恶血,瘀血血闭,破血癥积聚”等。清代唐容川在《血证论》中记有:“癥者 ......
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