Effect of prostaglandinª²E1 on hemodynamics of renal arterial blood flow in patients with diabetic nephropathy

    SUN Jiª²Feng, ZHAO Baiª²Shan, JIAO Kai, YANG Jie, LI Zhanª²Ting, DU Deª²Wei, DUAN Yunª²You

    Department of Nephrology, Department of Diagnostic Ultrasound, Department of Endocrinology, Tangdu Hospital, Fourth Military Medical University, Xi¬ðan 710038, China

    ¡¾Abstract¡¿ AIM: To observe the effect of prostaglandinª²E1 (PGE1) on the hemodynamics of renal arterial blood flow in diabetic nephropathy (DN). METHODS: The renal color Doppler ultrasound was employed to examine renal arterial blood flow before and after treatment with PGE1 in 95 DN patients and 88 normal controls. RESULTS: The hemodynamic parameters of renal arterial blood flow in DN patients, especially the inner diameter of renal artery, velocity time integral and resistent index, were significantly changed (P<0.01); after treatment with PGE1 the parameters mentioned above were changed as well (P<0.05)£»the levels of BUN and Cr increased from (10.1¡À5.4) mmol/L,(194¡À51) ¦Ìmol/L before treatment to (7.9¡À6.0) mmol/L,(99¡À35) ¦Ìmol/L after treatment, and the amount of urine increased from (948¡À128) mL/d to (1242¡À373) mL/d; the parameters of renal function were improved significantly(P<0.05). CONCLUSION: The hemodynamics of renal arterial blood flow in DN patient was changed, which was caused by the coagulation disorders and fibrinolytic disorders. The application of PGE1 in the treatment of renal failure is beneficial to delay the deterioration of renal function. ......