莪术对SGC7901胃癌细胞COX-1, COX-2, VEGF和PGE2表达
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沈 洪, 刘增巍, 朱萱萱, 张 坤, 王 伟,
莪术;胃癌;SGC7901细胞;环氧合酶;血管内皮生长因子;前列腺素E2沈洪,刘增巍,朱萱萱,张坤,王伟,郭青龙,袁胜涛.莪术对SGC7901胃癌细胞COX-1,COX-2,VEGF和PGE2表达的影
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沈洪, 刘增巍, 江苏省中医院消化科 江苏省南京市 210029
朱萱萱, 江苏省中医院动物实验室 江苏省南京市 210029
张坤, 王伟, 郭青龙, 袁胜涛, 中国药科大学肿瘤药理实验室 江苏省南京市 210009
沈洪, 1992年南京中医药大学中医内科学博士研究生毕业, 2001年留学于日本, 博士生导师, 主要从事消化道肿瘤的防治研究.
江苏省自然科学基金资助项目, No. BK2001186
通讯作者: 刘增巍, 210029, 江苏省南京市汉中路155号, 江苏省中医院消化科. dixiao96@126.com
电话: 025-82082660 传真: 025-86618942
收稿日期: 2006-03-06 接受日期: 2006-03-30
Effect of Ezhu on expression of cyclooxygenase, vascular endothelial growth factor and prostaglandin E2 in human gastric cancer cell line SGC7901
Hong Shen, Zeng-Wei Liu, Xuan-Xuan Zhu, Kun Zhang, Wei Wang, Qing-Long Guo, Sheng-Tao Yuan
Hong Shen, Zeng-Wei Liu, Department of Digestive Diseases, Jiangsu Hospital of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Xuan-Xuan Zhu, Department of Animal Experiment, Jiangsu Hospital of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Kun Zhang, Wei Wang, Qing-Long Guo, Sheng-Tao Yuan, Laboratory of Tumor Pharmacology, China Pharmaceutical University, Nanjing 210009, Jiangsu Province, China
Supported by the Natural Science Foundation of Jiangsu Province, No. BK2001186
Correspondence to: Dr. Zeng-Wei Liu, Department of Digestive Diseases, Jiangsu Hospital of Traditional Chinese Medicine, 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. dixiao96@126.com
Received: 2006-03-06 Accepted: 2006-03-30
Abstract
AIM:To investigate the effect of Ezhu on the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2) in human gastric cancer cell line SGC7901.
METHODS: The MTT method was used to observe the suppression of the human gastric cancer (SGC7901) cells treated with Ezhu. By drawing the suppression rate curves, we selected the appropriate Ezhu concentration at the 25% proliferation suppression rate as experimental concentration ......
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