趋化因子受体CXCR4/CXCL12信号转导通路在结直肠癌肝转移中的作用
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马向涛, 余力伟, 张在兴, 王 杉, 杜如昱,
结直肠癌;信号转导;趋化因子;转移马向涛,余力伟,张在兴,王杉,杜如昱,崔志荣.趋化因子受体CXCR4,CXCL12信号转导通路在结直肠癌肝转移中的作用. 世界华人消化杂志2006;14(
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马向涛, 余力伟, 张在兴, 北京市海淀医院外科 北京市 100080
王杉, 杜如昱, 崔志荣, 北京大学人民医院外科, 外科肿瘤研究室 北京市 100044 马向涛, 2002年北京大学医学博士, 主治医师, 主要从事消化系统肿瘤的分子生物学研究.
国家自然科学基金资助项目, No. 30271269
通讯作者: 马向涛, 100080, 北京市海淀区中关村大街29号, 北京市海淀医院外科. xiangtao_ma@pku.org.cn
电话: 010-82619999-1887 传真: 010-62653601
收稿日期: 2006-03-26 接受日期: 2006-04-16
Role of chemokine receptor CXCR4/CXCL12 signaling pathway in hepatic metastasis of colorectal carcinoma
Xiang-Tao Ma, Li-Wei Yu, Zai-Xing Zhang, Shan Wang, Ru-Yu Du, Zhi-Rong Cui
Xiang-Tao Ma, Li-Wei Yu, Zai-Xing Zhang, Department of Surgery, Beijing Haidian Hospital, Beijing 10080, China
Shan Wang, Ru-Yu Du, Zhi-Rong Cui, Department of Surgery and Division of Surgical Oncology, Peking University People’s Hospital, Beijing 100044, China
Supported by National Natural Science Foundation of China, No. 30271269
Correspondence to: Dr. Xiang-Tao Ma, Department of Surgery, Beijing Haidian Hospital, 29 Zhongguancun Street, Beijing 100080, China. xiangtao_ma@pku.org.cn
Received: 2006-03-26 Accepted: 2006-04-16
Abstract
AIM:To investigate the potential role of chemokine receptor CXCR4/CXCL12 signal transduction pathway in hepatic metastasis of colorectal carcinoma.
METHODS:CXCR4 and CXCL12 expression were detected in tissue samples from 60 patients with colorectal carcinoma representing various clinicopathological parameters by Western blot analysis.
RESULTS:The levels of CXCR4 and CXCL12 proteins expression were increased significantly in colorectal cancer as compared with those in the adjacent normal mucosa (P < 0.05). In the 10 patients with lymph node metastasis, the expression of CXCR4 and CXCL12 were also markedly higher than those in those without metastasis (CXCR4: 3.9 ± 0.5vs 2.2 ± 0.3, P < 0.05; CXCL12: 3.6 ± 0.5 vs 2.4 ± 0.3, P < 0.05). The over-expression of CXCR4 and CXCL12 proteins were correlated with TNM staging, and they were highly elevated in colorectal cancer at Ⅲ and Ⅳstages as compared with those at Ⅰ and Ⅱ stages (CXCR4: 3 ......
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