细胞凋亡基因、肿瘤侵袭相关蛋白酶及血管内皮生长因子在胃癌分型中的表达和意义
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刘易欣, 赵春歌, 赵秀兰, 潘彦珞
Bcl;Bax;Cath-D;血管内皮生长因子;胃癌;生物行为;Lauren's分型刘易欣,赵春歌,赵秀兰,潘彦珞.细胞凋亡基因、肿瘤侵袭相关蛋白酶及血管内皮生长因子在胃癌分型中的表达和意义.Q
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刘易欣, 赵春歌, 赵秀兰, 潘彦珞, 天津医科大学病理教研室 天津市 300070
刘易欣, 1986年毕业于天津医学院, 1990年北医大病理系进修, 1994-1995年在中科院生物膜与膜生物工程国家重点实验室从事客座研究, 从事荧光免疫病理学, 肿瘤及胃肠疾病的研究.
通讯作者: 潘彦珞, 300070, 天津市和平区气象台路22号, 天津医科大学病理教研室. panyanlu70@yahoo.com.cn
电话: 022-23542527
收稿日期: 2006-05-09 接受日期: 2006-05-24
Expression and significances of apoptosis gene, invasion-associated proteases and vascular epithelial growth factor in Lauren’s classification of gastric carcinoma
Yi-Xin Liu, Chun-Ge Zhao, Xiu-Lan Zhao, Yan-Luo Pan
Yi-Xin Liu, Chun-Ge Zhao, Xiu-Lan Zhao, Yan-Luo Pan, Department of Pathology, Tianjin Medical University, Tianjin 300070, China
Correspondence to: Yan-Luo Pan, Department of Pathology, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China. panyanlu70@yahoo.com.cn
Received: 2006-05-09 Accepted: 2006-05-24
Abstract
AIM:To explore distinctive biological behavior in the intestinal-type gastric carcinoma and diffuse-type gastric carcinoma, according to the expression of Bcl-2, Bax, Cath-D and vascular epithelial growth factor (VEGF).
METHODS: Immunohistochemistry SP method was performed to detect the expression of Bcl-2, Bax, Cath-D and VEGF in 36 cases of intestinal-type gastric carcinoma, 38 cases of diffuse-type gastric carcinoma, and their corresponding normal gastric tissues.
RESULTS: The expression of Bcl-2, Bax, Cath-D and VEGF were significantly higher in gastric carcinoma than those in the normal controls (44.59% vs 27.30%; 58.11% vs 71.62%; 77.00% vs 21.60%; 71.62% vs 14.86%; all P < 0.05). The positive expression of Bcl-2 and Cath-D were markedly higher in diffuse-type gastric carcinoma than those in intestinal-type one (29.14 ± 24.70 vs 19.80 ± 27.37; 52.59 ± 33.76 vs 29.21 ± 39.67; both P < 0.05), while the expression of Bax was notably lower in the former (32.56 ± 35.55 vs 47.74 ± 27.43, P < 0 ......
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