肺虚痰阻_____]_肺虚痰阻;

肺虚痰阻大鼠肺组织核因子κB 和环氧合酶2 mRNA的表达

http://www.100md.com 《中西医结合学报》 2005年第2期

肺虚痰阻,,],肺虚痰阻;,核因子κB;,环氧合酶2,肺虚痰阻大鼠肺组织核因子κB和环氧合酶2mRNA的表达,1材料与方法,2结果,3讨论,[参考文献]

     [摘要] 目的：探讨核因子κB(nuclear factorkappa B, NFκB)和环氧合酶2(cycloxygenase2, COX2)在肺虚痰阻大鼠发病中的意义和化痰1号作用的机制。方法：采用二氧化硫烟薰和寒冷刺激建立SD大鼠肺虚痰阻模型，应用免疫组化法检测正常组、肺虚痰阻模型组及化痰1号治疗组大鼠支气管上皮细胞NFκB的表达及RTPCR检测肺组织COX2 mRNA的表达。结果：模型组NFκB和COX2 mRNA的表达高于正常组(P<0.01)，中药治疗后，NFκB和COX2 mRNA的表达明显降低，与模型组比较有显著性差异(P<0.01)。结论：NFκB和COX2 mRNA的表达升高在痰邪致病中起着重要作用，化痰1号可能通过调节NFκB和COX2 mRNA的表达而起到化痰作用。

    [关键词] 肺虚痰阻; 核因子κB; 环氧合酶2

    Expression of NFκB and COX2 mRNA in rats with phlegm obstruction due to lungdeficiency

    WANG Ping1, WU XiuYan2, ZHANG MaoLin1, TIAN DaiZhi3, LIU SongLin4

    (1. Department of Basic Theory of Traditional Chinese Medicine, Hubei College of Traditional Chinese Medicine, Wuhan, Hubei Province 430061, China; 2. Department of Traditional Chinese Internal Medicine, Hubei College of Traditional Chinese Medicine, Wuhan, Hubei Province 430061, China; 3. Central Laboratory, Hubei College of Traditional Chinese Medicine, Wuhan, Hubei Province 430061, China; 4. Department of Exogenous Febrile Diseases, Hubei College of Traditional Chinese Medicine, Wuhan, Hubei Province 430061, China) ......

百拇医药网 http://www.100md.com/html/DirDu/2006/06/10/00/70/37.htm

您现在查看是摘要页，全文长 12004 字符。