人参皂苷联合地塞米松防治经动脉化疗栓塞术后综合征的前瞻性双盲随机对照研究
经动脉化疗栓塞术,,],肝癌;,经动脉化疗栓塞术;,地塞米松;,人参皂苷,1资料与方法,2结果,3讨论,[参考文献]
[摘要] 目的：观察人参皂苷及小剂量糖皮质激素防治经动脉化疗栓塞术(transcatheter arterial chemoembolization, TACE)后综合征的效果。方法：采用随机、双盲、对照设计方法，将80例原发性肝癌患者分成4组，每组20例。A组为安慰剂组，B组为地塞米松组，C组为人参皂苷组，D组为地塞米松加人参皂苷组。观察TACE后临床症状、理化指标、肝功能分级等变化。结果：地塞米松加人参皂苷可显著降低恶心、呕吐、发热等症状的发生率及症状持续的中位时间,并对肝功能有一定保护作用。与安慰剂比较，地塞米松、人参皂苷单药在改善某一症状方面有较好作用(P<0.05)，但在全面防治综合征方面不及地塞米松加人参皂苷。结论：人参皂苷联合地塞米松可有效防治TACE后综合征。[关键词] 肝癌; 经动脉化疗栓塞术; 地塞米松; 人参皂苷
Ginsenosides combined with dexamethasone in preventing and treating postembolization syndrome following transcatheter arterial chemoembolization: A randomized, controlled and doubleblinded prospective trial
FENG YingLu, LING ChangQuan, ZHU DeZeng, YU ChaoQin, CHEN Zhe, LI Bai
(Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China)
ABSTRACT Objective:To observe the effect of ginsenosides (GS) and low dose glucocorticoid in preventing and treating the postembolization syndrome following transcatheter arterial chemoembolization (TACE). Methods: Eighty patients with primary liver carcinoma were randomly divided into 4 doubleblinded groups, with 20 patients in each group. Patients in groups A, B, C, D were treated with placebo, dexamethasone (Dex), GS, Dex and GS, respectively. The changes of clinical symptoms and laboratory tests after TACE were observed. Results: Dex combined with GS markedly decreased the occurrence ratio and lasting time of the symptoms such as nausea, vomiting, fever and pain, and protected the function of liver as compared with the placebo (P<0.05). Single use of Dex or GS improved some symptoms as compared with the placebo, but it was not as good as the combination of Dex and GS. Conclusion: Dex combined with GS can effectively prevent and treat the postembolization syndrome following TACE. ......
您现在查看是摘要页，全文长 10016 字符。