卵巢癌_____卵巢癌;预后;HLA抗原

卵巢恶性上皮性肿瘤中HLADR表达及树突细胞浸润的意义

http://www.100md.com 《广东药学院学报》 2000年第4期

卵巢癌,,卵巢癌;预后;HLA抗原,免疫学;S100蛋白;树突细胞;免疫组织化学,1材料和方法,2结果,3讨论,参考文献

     摘要目的：探讨卵巢癌中HLADR抗原表达和树突细胞浸润的情况及其意义。方法：用免疫组化SP法对卵巢恶性上皮性肿瘤(48例)、良性上皮性肿瘤(30例)及正常卵巢(30例)的HLADR抗原表达及树突细胞浸润情况进行对照研究。结果：正常卵巢组织中HLADR阴性,卵巢恶性上皮性肿瘤中HLADR表达阳性率为52.08%(P<0.01)；HLADR表达率与肿瘤分化程度相关(P<0.01)，且与预后相关(P<0.05)；卵巢恶性上皮性肿瘤中树突细胞(S100+DC)浸润显著增加(P<0.001)；S100+DC浸润与肿瘤间质淋巴细胞浸润相关(P<0.01)；S100+DC浸润与肿瘤患者预后相关(P<0.05)。结论：卵巢恶性上皮性肿瘤中HLADR抗原表达增强，树突细胞浸润增加，二者可能是局部抗肿瘤免疫的重要环节；HLADR和树突细胞浸润数量可作为提示卵巢癌患者预后的指标。

    关键词卵巢癌;预后;HLA抗原/免疫学;S100蛋白;树突细胞;免疫组织化学

    XIAO Guohong, CHEN Huizhen,ZHANG Guiqing,ZHENG Xiuling

    Second Municipal People's Hospital,GuangZhou，Guangdong 510150

    Abstract Objective:To investigate the clinical and immunological significance of HLADR antigen expression and dendritic cell infiltration in epithelial ovarian cancer. Method: Samples of 108 cases including normal ovarian tissue (n=30),benign (n=30) and malignant epithelial ovarian tumor (n=48) were used in a comparative study. The SP immunohistochemical stain method was used.Result:HLADR antigen positive rate was significantly higher in the malignant group (52.08%) than that in benign group (10%) and in normal group(0%) (P<0.01). There was a correlation between the HLADR expression rate and the tumuor differentiation and between HLADR expression and the prognosis. The number of infiltrating dendritic cells (S100+DC) was much higher in malignant(538.17±255.01) than that in benign group(345.96±226.81) and in normal group (335.15±160.32) (P<0.01). There was a correlation between the dendritic cell (S100+ DC) infiltration and the intertumour lymphocyte infiltration (P<0.01) and the prognosis (P<0.05).Conclusion:It was shown that HLADR antigen expression and dendritic cells infiltration in epitherial ovarian cancer increased, which could play a important role in antitumour immunity. The expression of HLADR antigen and the grade of dendritic cells infiltration in epitherial ovarian cancer is the indicator for the prognosis. ......

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