【摘要】 目的：观察帕罗西汀治疗脑卒中后抑郁(PSD)患者的疗效和不良反应。方法： 随机将82例脑卒中后抑郁患者分为两组,分别用帕罗西汀和阿米替林治疗8周。以Hamilton抑郁量表(HAMD)和副反应量表(TESS)作为评定工具。结果：帕罗西汀组与阿米替林组两组间的HAMD评分差异均无显著性， 帕罗西汀组不良反应较阿米替林组少且轻。结论：帕罗西汀是治疗脑卒中后抑郁有效、安全的药物。

    【关键词 】 帕罗西汀; 阿米替林; 脑卒中后抑郁

    A comparative study of paroxetine and amitriptyline in post-stroke depression

    LUO Ru-qin,HU Chun-hua,CHEN Ren-yun,et al

    (Wudong Railway Psychiatric Hospital,Wuhan 430084,China)

    【Abstract】 Objective：To compare the efficacy and side effects of paroxetine and amitriptyline in the treatment of post-stroke depression (PSD). Methods:82 patients with post-stroke depression were randomly divided into the treatment groups of paroxetine or amitriptyline for eight weeks.The efficacy and side effects were assessed with HAMD and TESS.Results: No remarkable differences were found in HAMD scores between two groups,but the side effects of paroxetine were fewer and milder than that of amitriptyline. Conclusions: Paroxetine is an effective and safe drug in the treatment of post-stroke depression. ......