金丝桃__

金丝桃清除活性氧作用研究

http://www.100md.com 《广东药学院学报》 2000年第4期

金丝桃,,金丝桃；化学发光；脂质过氧化；抗氧化作用；自由基,1材料与仪器,2实验方法,3结果与讨论,参考文献

     摘要目的：对金丝桃不同部位提取物的清除活性氧活性进行了实验研究。方法：用化学发光法研究了金丝桃提取物对O2-[]·、H2O2的清除作用；用分光光度法研究了提取物对·OH的清除作用以及对H2O2引起红细胞损伤和由Fe2+-Vit C引起线粒体膨胀的保护作用。结果：金丝桃提取物能有效地清除O2-[]·、H2O2和·OH，对H2O2引起的红细胞损伤有一定的保护作用，同时能抑制由Fe2+-Vit C引起的线粒体膨胀。结论：金丝桃提取物有良好的清除活性氧活性。

    关键词金丝桃；化学发光；脂质过氧化；抗氧化作用；自由基

    Eliminating Active Oxyradical

    XIANG Guangya,HAO Qiaoling,YUAN Jinwei,ZHOU Yikai

    Institute of Enviromental Medicine of Tongji Medical College,Central China University of Sciences and Technologies, Wuhan, Hubei 430030

    Abstract Objective:To study the effect of the extracts of Hypericum Chinense on eliminating active oxyradical. Methods: Chemiluminescence method and spectrometric method were used to measure the eliminating effect of Hypericum chinense on superoxide anion (O2-[]·)、hydrogen peroxide (H2O2 ) and hydroxyl radical (·OH). Its protective effects on damage and lipid peroxidation of red blood cell induced by H2O2 and mitochondria swelling induced by Fe2+Vit C were also investigated. Results: The extracts of hypericum chinense could eliminate O2-[]·、H2O2 and ·OH effectively .They could also prevent the damage and lipid peroxidation of red blood cell induced by hydrogen peroxide and the mitochondria swelling induced by Fe2+Vit C. Conclusion:The results showed that Hypericum chinense was effective in eliminating active oxyradical. ......

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