Protective effect of extract of crocus sativus on electroretinogram of rabbits with chronic ocular hypertension

    WANG Changª²Peng, YANG Xinª²Guang, YAN Hong, WANG Weiª²Nong, LIU Yan

    Department of Ophthalmology,Tangdu Hospital, Fourth Military Medical University,Xi¬ðan 710038,China

    ¡¾Abstract¡¿ AIM: To explore the protective effect of extract of crocus sativus on function of rabbits¬ð retina damaged by chronic ocular hypertension(OHT). METHODS: Thirty rabbits were randomly divided into control group, OHT group and three treated groups . The OHT was induced by injecting 3 g/L carbomer into anterior chamber of the OHT group and three treated groups,while paracentesis was performed in the control group but without the injection of carbomer. Rabbits in three treated groups were treated with extract of crocus sativus every day.The amplitude of bª²wave and Opsª²wave of electroretinogram(ERG) were measured before injection and one,two and four weeks after. RESULTS: Amplitudes of bª²wave and Opsª²wave of habbits in OHT group were significantly lower than those of habbits in control group and treated groups. Amplitudes of bª²wave and Opsª²wave of habbits in control group had no significant difference with those of treated group¢ò,¢ó. CONCLUSION: The retinal function of rabbit was damaged by OHT,which manifested by descenting of amplitudes of bª²wave and Opsª²wave .The extract of crocus sativus had the protective effect on the function of retina damaged by OHT. ......