【摘要】 目的：探讨重性抑郁症共病焦虑障碍患者与重性抑郁症患者儿茶酚氧位甲基转移酶(COMT)基因多态性的差异。方法： 应用聚合酶链反应(PCR)和限制性片段长度多态性(RFLP)技术，检测15例重性抑郁症共病焦虑障碍患者(研究组)和15例单纯诊断为重性抑郁症患者(对照组)的COMT基因多态性。结果：研究组患者与对照组患者相比，无论是等位基因A、等位基因G频率还是基因型A/A、A/G及G/G频率均无显著差异；只是在等位基因A频率上，研究组的男性患者(22.22%)显著高于对照组的男性患者(5.56%)。结论：抑郁与焦虑共病的基因多态性研究值得进一步深入研究。

    【关键词 】 重性抑郁症；焦虑障碍；儿茶酚氧位甲基转移酶；多态现象(遗传学)

    The polymorphism of catechol-O-methyltransferase gene between the patients with major depression and the patients with major depression co morbidity anxiety disorder

    YU Chang-hong，WU Huai-an，HU Ji-ze，et al

    (Shenzhen Mental Health Institute,Shenzhen518020,China)

    【Abstract】 Objective：To investigate the difference of the polymorphism of catechol- O-methyltransferase gene between the patients with major depression and the patients with major depression co morbidity anxiety disorder. Methods:15 patients with major depression co morbidity anxiety (study group) and 15 patients with major depression (control group) diagnosed by DSM-IV were involved in the study using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) technique.Results: There was no significant difference between two groups in the frequency allele A and allele G. The statistical difference was not found between two groups in the genotype A/A, A/G and G/G too. But the frequency of allele A of the male patients in the study group (22.22%) was statistically higher than that of the control group (5.56%).Conclusions: The polymorphism of gene in the patients with major depression co morbidity anxiety deserved us to study further. ......