慢性肾功能衰竭与慢性炎症反应的关系
慢性肾功能衰竭,,慢性肾功能衰竭;慢性炎症反应;C反应蛋白;白细胞介素-6;白细胞介素-10,摘要,关键词,1对象与方法,2结果,3讨论,参考文献
摘 要目的:深入研究慢性炎症反应与慢性肾功能衰竭的关系。方法:将2001年6月至2004年6月在我院住院的慢性肾功能衰竭(CRF)患者126例分为4组,检测其血肌酐(Scr)、肌酐清除率(Ccr)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)。CRP、IL-10 采用ELISA法测定,IL-6采用放射免疫法测定。结果:CRF患者各期的CRP、IL-6、IL-10水平均增高,与对照组比较,差异均有非常显著性( P<0.01); CRF患者CRP、IL-6、IL-10与血肌酐呈正的直线相关关系,与肌酐清除率呈负的直线相关关系; 急性时相蛋白CRP、炎性介质IL-6与抗炎介质IL-10均有相关性 。结论:CRF患者急性时相蛋白CRP、致炎性介质IL-6及抗炎性介质IL-10水平增高且随着肾功能损害程度的加重,急性时相蛋白CRP、致炎性介质IL-6及抗炎性介质IL-10水平进一步增高;急性时相蛋白CRP、致炎性介质IL-6与抗炎性介质IL-10有一定的相关性。
关键词 慢性肾功能衰竭;慢性炎症反应;C反应蛋白;白细胞介素-6;白细胞介素-10
中图分类号 R692.5
The Chronic Inflammatory Status in Patients with Chronic Renal Failure
LIU Liping,WANG CaiLi
(Kidney Medicine Department,Baotou Medical College,Baotou 014010,China)
Abstract Objective:To study the relationship between the status of chronic inflammation and deterioration of renal function in patients with chronic renal failure Methods: Serum CRP.(with ELISA),IL-10(with ELISA),IL-6(with RIA),and creatinine(with bio-chemistry)levers were determineed in 126 patients with CRF of various stages who had been under the treatment in our hospital from June 2001 to June 2004.Results:In all these patients ......
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