局部麻醉药_

高效毛细管电泳法分离检测盐酸普鲁卡因和盐酸利多卡因

http://www.100md.com 《广东药学院学报》 2000年第4期

局部麻醉药,,高效毛细管电泳;安培检测;微铂电极;局部麻醉药,1实验部分,2结果与讨论,3结论,参考文献

     摘要建立了两种局部麻醉药—盐酸普鲁卡因和盐酸利多卡因的高效毛细管电泳方法。以微铂电极为工作电极，通过优化选择检测电位、缓冲溶液pH、工作电压等实验参数，盐酸普鲁卡因和盐酸利多卡因在5 min内可以得到较好的分离，检出限分别为4 μg/L,6 μg/L,回收率在96.3%～101.6%。方法简便，快速，重现性好，适合药物生产过程的质量控制和临床检测。

    关键词高效毛细管电泳;安培检测;微铂电极;局部麻醉药

    文献标识码:ADetermination of Procaini Hydrochloridum and Lidocaini Hydrochloridum by HighPerformance Capillary Electrophoresis Detection

    YANG Bingyi1, CHEN Zhicheng1, YANG Xiaoyun2

    (1.Dept. of Hygiene Chemistry,Guangdong College of Pharmacy, Guangzhou 510224;2.Department of Plant Protection, South China Agricultural University)

    Abstract A method for separation and determination of Procaini Hydrochloridum and Lidocaini Hydrochloridum by highperformance capillary electrophoresisamperometric detection with a micro Platinum electrode was described. The effects of detection potential and buffer pH were extensively investigated. Results showed that Procaini Hydrochloridum and Lidocaini Hydrochloridum were satisfactorily eluted in 5 minutes and the detection limits were 4 μg/L and 6 μg/L respectively. The recovery was 96.3%～101.6%.The method is simple, rapid and well reproducible ,and can be used as a reliable tool for the quality control and clinical analysis of Procaini Hydrochloridum and Lidocaini Hydrochloridum. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/06/10/00/79/35.htm

您现在查看是摘要页，全文长 6336 字符。