[摘要]目的探讨急性脑梗死病人血白细胞计数及血清IL-6水平的变化及其临床意义。方法 分别检测60例急性脑梗死病人(脑梗死组)急性期第1天白细胞计数及第1、3、7、14天血清IL-6水平，并与30例健康对照者(对照组)检测结果比较。结果 与健康对照组相比，脑梗死组病人血白细胞计数明显增高( t=7.826，P <0.01 )，血清IL-6水平在各时间点均高于对照组( t=9.797～31.768，P <0.01)。大梗死灶脑梗死组病人血白细胞计数及血清IL-6水平高于中梗死灶病人组( F=4.25、4.07，q=2.847、3.685，P< 0.05)和小梗死灶病人组( q=2.976 、3.563 ，P <0.05 )。重度脑梗死组病人血白细胞计数及血清IL-6水平均高于中度脑梗死组病人( F=5.657、5.463 ，q= 4.457、5.628 ，P< 0.01)和轻度脑梗死组病人( q=5.036、5.312，P<0.01)。结论 炎症反应可能是脑梗死病人急性期神经元损伤的原因之一;白细胞计数及血清IL-6水平的升高与疾病的严重程度有关，并可能成为疾病预后的判断依据。

    [关键词]脑梗死;白细胞计数;白细胞介素6

    CHANGES OF LEUCOCYTE COUNTS AND LEVEL OF SERUM IL-6 IN PATIENTS WITH CEREBRAL INFARCTION

    YUAN HAI-CHENG， WANG LING， CHEN JING， et al

    (Department of Neurology， The Second Affiliated Hospital of Qingdao U-niversity Medical College， Qingdao 266042，China)

    [ABSTRACT] Objective To investigate the changes of leucocyte counts and the level of serum IL-6 in patients with cerebral infarction and their clinical significance. Methods The serum IL-6 was analysed with ELISA in 60 patients with cerebral infarc-tion during different phases (on 1 d ......