[摘要]目的 探讨肿瘤坏死因子-β(TNF-β)+252基因单核苷酸多态性与胃癌病人癌性恶液质的关系。方法105例营养不良胃癌病人，按照近6个月体质量的减轻率分成3组:A组，0～5%;B组，6%～10%;C组，>10%。用PCR结合限制性内切酶检测胃癌病人及110例正常志愿者TNF-β+252单核苷酸多态性。结果 TNF-β+252A(TNFB2)出现的频率在胃癌组和对照组差异无显著性( P >0.05)。在胃癌病人中，TNFB2出现的频率在A、B、C各组差异亦无显著性( P >0.05);恶液质病人TNFB2出现的频率与对照组比较差异无显著性( P >0.05)。结论 TNF-β+252基因单核苷酸多态性与胃癌恶液质的发生无相关性。

     [关键词] 胃肿瘤;恶病质;多态性，单核苷酸

    ASSOCIATION OF IL GENE MONONUCLEOTIDE POLYMORPHISMS WITH DYSCRASIA IN GASTRIC CANCER

    ZHANG DIAN- LIANG， LI YUN-DONG， ZHANG MEI-LI， et al

    (Department of General Surgery， The Affiliated Hospital of Qingdao University Medical College， Qingdao 266003， China)

    [ABSTRACT]ObjectiveTo evaluate the association of TNF-β+252 mononucleotide polymorphisms with dyscrasia related to gastric cancer. MethodsThis study was carried out in 105 gastric cancer patients with malnutrition who were divided into three groups according to their weight loss in the last six months: group A ......