脓毒血症过程中大鼠皮层诱发电位的变化
脓毒血症,,脓毒血症；脓毒性休克；皮层诱发电位；大鼠,摘要,关键词,1材料与方法,2结果,3讨论,参考文献
摘要: 目的：观察脓毒血症发展过程中大鼠大脑皮层诱发电位(CSEP)的变化，探讨脓毒血症时脑电位变化的病理生理基础。方法：100只Wistar大鼠随机分为假手术组与脓毒血症组，每组50只。脓毒血症组采用盲肠结扎穿刺术复制脓毒血症模型，假手术组除不做盲肠结扎穿刺术外余同脓毒血症组，2组又按术后时间分为4、8、12、16、20 h 5组，每组10只,观察各组大鼠的一般状况及CSEP正波与负波潜伏期的变化，并进行比较。结果：(1)假手术组大鼠一般状况良好，脓毒血症组大鼠精神萎靡，呼吸明显加快。 (2)脓毒血症组大鼠随术后时间延长，CSEP正、负波潜伏期有延长的趋势，术后12、16、20 h组的正、负波潜伏期明显长于术后4.8 h组，差异有统计学意义(P<0.05)；脓毒血症组12、16、20 h CSEP正、负波潜伏期与假手术组相应时间点,差异均有统计学意义(P<0.05~0.01)。结论：脓毒血症过程中随病情的发展大鼠CSEP正、负波潜伏期有逐渐延长的趋势，为脓毒血症的基础与临床研究提供了依据。关键词： 脓毒血症；脓毒性休克；皮层诱发电位；大鼠
Effect of sepsis on cortical somatosensory evoked potential in rats
ZHANG Xiaoting, ZHANG Jianlong, MA Qi
(Deparment of Pathohysiology, Preclinical Medicine Colloge, Xinjiang Medical University,
Urumqi 830054, China)
Abstract: Objective: To observe the change of cortical somatosensory evoked potential (CSEP), to explore the basis of pathophysiology of the change of brain′s potential during sepsis in rats. Methods: One hundred Wistar rats were randomly devided into sham operation group and sepsis group, 50 in each group. And each group was also devided into 5 groups of 4, 8, 12, 16, 20 h after operation. The sham operation group underwent laparotomy only. The sepsis group received laparotomy and cecal ligation plus punctures (CLP). Latencies of P wave and N wave of CSEP were measured in each group and were compared with. Results: (1) The common state of rats in the sham operation group was good. While rats in the sepsis group were depressed and had accelerated breathing. (2) Latencies of P wave and N wave prolonged gradually with the development of sepsis in the sepsis group (P<0.05). And at 12, 16, 20 h they prolonged significantly in the sepsis group as compared with those in the sham operation group (P<0.05). Conclusion: It is concluded that latencies of P wave and N wave of CSEP prolong obviously with the development of sepsis. The experiment provides one basis in the preclinic and the clinic studyies of the sepsis. ......
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