Effect of branchedª²chain amino acid on total parenteral nutritional support in patients after total gastrectomy: A prospective study

    LI Xiangª²Yang, WANG Weiª²Zhong, CHEN Dongª²Li

    Department of Gastrointestinal Surgery, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To investigate the effect of branchedª²chain amino acid (BCAA) enriched solution on total parenteral nutritional support in patients after total gastrectomy. METHODS: Forty patients who underwent total gastrectomy were enrolled in the prospective, randomized and singleª²blindª²controlled study£¬and were randomized to receive total parenteral nutrition (TPN) with either BCAA enriched solution(n=20, experiment group) or amino acid solution(18ª²F) (n=20, control group). TPN was infused to all patiens with equal calorie and equal nitrogen by central or peripheral vein during the immediate 7 d after operation. Meanwhile, nitrogen balance was monitored by collecting 24ª²h urine for 7 d. The indices were investigated such as the body weight, hand grip strength, triceps skinª²fold thickness, upper arm circumference, serum levels of total protein, albumin, prealbumin, transferrin, and Cª²reactive protein before and after operation. RESULTS: The positive nitrogen balance in the experimental group was got on the 2nd postoperative day, 4 d earlier than that in the control group, and the levels of nitrogen balance on the 3rd postoperative day were varied significantly between the 2 groups (P<0.01). After 7ª²d TPN, the hand grip strength (P<0.05), serum levels of prealbumin (P<0.01), and transferrin (P<0.01) in the experimental group increased more significantly than those in the control group. CONCLUSION: The BCAA enriched solution can improve the nutritional status and achieve favorable prognosis in the patients receiving total gastrectomy. ......