【摘要】 目的 观察和评估拉米夫定单药或与α-2b干扰素联合治疗慢性乙型肝炎患者的疗效。方法 共有59例患者，其中23例入选拉米夫定组，拉米夫定0.1g口服治疗，每天1次；36例入选联合组，应用拉米夫定2周后加用α-2b干扰素300万u肌肉或皮下注射，每周3次，连续24周后继续应用拉米夫定。结果 拉米夫定单药治疗在ALT应答、HBeAg及HBV DNA转阴率上两组差异无显著性。结论 联合应用α-2b干扰素和拉米夫定具有较好的疗效和耐受性，因而在目前慢性乙型肝炎患者的抗病毒治疗中，联合治疗有望成为比拉米夫定单药治疗更加令人满意的方案。

     【关键词】 拉米夫定； 干扰素 ； 慢性乙型肝炎

    A clinical observation of patients with chronic hepatitis B treated with lamivudine or a combination course

    YUE Gui-hong， ZENG Meng-xia.Qinghai Provincial Corps Hospital of Chinese People’s Army Police Forces.Xining,Qinghai 810000,China

    【Abstract】 Objective To observe and investigate the curative effection of patients with chronic hepatitis B treated with lamivudine or both lamivudine and interferon α-2b.Methods All 59patients were randomly divided into 2 groups;23 patients orally take lamivudine 0.1g per day, the other 36 patients were given a 24 weeks, course of interferon α-2b or intramuscular injection 300 wu daily and 3 times a week.After they had taken lamvudine orally for 2 weeks,the last group will continue to have lamivudine after the injection course.Results Compared with the combination course ,patients of the lamivudine group have no difference in response of the ALT and HBeAg ,HBV DNA negative rate.Conclusion Patients take a combination therapy of both lamivudine and gain a better curative effection and a better toleration .In the anti-virus therapy of chronic hepatitis B,a combination project may gain a satisfactory result. ......