[摘要]目的 探讨血清锌(Zn)、生长激素(GH)和胰岛素样生长因子-1(IGF-1)与儿童银屑病发病的关系。方法 采用原子吸收分光光度法(AAS)检测52例银屑病病儿和46例健康对照者血清Zn的水平;采用放射免疫分析法(RIA)检测血清GH基础值和IGF-1的水平。结果 银屑病病儿血清Zn水平明显低于正常对照组，差异有极显著性( t=4.59，P <0.01)。青春期前银屑病病儿血清GH基础值和IGF-1水平均高于正常对照组，差异有极显著性( t=-4.17、3.55，P <0.01);青春期银屑病病儿血清GH基础值和IGF-1水平与正常对照组比较差异无显著性( t=1.55、-1.98，P >0.05)。结论 Zn、GH和IGF-1可能参与了儿童银屑病的发病。

     [关键词] 锌;促生长素;胰岛素样生长因子1;银屑病;儿童

    RELATIONSHIP BETWEEN ZINC， GROWTH HORMONE， INSULIN-LIKE GROWTH FACTOR-1 AND PSORIASIS IN CHIL-DREN

    YU XIAO-JING，WANG GUI-ZHI， YU YE-JUN， et al

    (Department of Dermatology， The Affiliated Hospital of Qingdao University Medical College， Qingdao 266003， China)

    [ABSTRACT]ObjectiveTo investigate the relationship between serum zinc (Zn)， growth hormone (GH) ，insulin-like growth factors 1(IGF-1) and psoriasis in children. MethodsFifty-two children with psoriasis and 46 healthy controls were en-rolled in this study. The serum levels of Zn were measured by atomic absorption spectrophotometry (AAS) ......