尿结石_____尿结石;_尿纤溶活性;

α亚麻酸对草酸钙结石大鼠尿纤溶活性影响的实验研究

http://www.100md.com 《新疆医科大学学报》 2006年第5期

尿结石,,尿结石;,尿纤溶活性;,α亚麻酸,摘要,关键词,1材料与方法,2结果,3讨论,参考文献

     摘要：目的：探讨尿纤溶活性在尿结石形成过程中的保护作用以及α亚麻酸(αLNA)对草酸钙结石鼠纤溶活性的影响。方法： 75只雄性Wistar成年大鼠随机分成5组，阴性对照组饲以普通饲料，阳性对照组饲以高脂饲料，成石组饲以高脂饲料加诱石剂饮水，苏子油组饲以高脂饲料加诱石剂饮水并每日苏子油灌胃(2 g/只)，葵花籽油组饲以高脂饲料加诱石剂饮水并每日葵花籽油灌胃(2 g/只)。实验8周后检测各组大鼠血清总胆固醇(TC)、甘油三酯(TG)、血纤溶酶原激活物(tPA)水平,并对各组进行比较。结果：苏子油组和葵花籽油组血清TC和TG水平显著低于阳性对照组(P<0.05~0.01)，成石组tPA水平明显低于阴性对照组和苏子油组(P<0.01)。结论：尿纤溶活性是一种重要的抗结石形成而保护机体健康的因素，αLNA可提高草酸钙结石鼠尿纤溶活性，抑制尿结石形成。

    关键词：尿结石; 尿纤溶活性; α亚麻酸

    Experimental study on the αLinolenic acid effect to the urinary fibrinolytic

    activity in calcium oxalate urolithiasis rats

    LIANG Ying, LIU Jinbao, WANG Jun, et al

    (Department of Nutrition and Food Hygiene, Public Health College, Xinjiang Medical University,

    Urumqi 830054, China)

    Abstract: Objective: To investigate the protective role of urinary fibrinolytic activity in urinary stone formation and the effect of αLinolenic acid on the fibrinolytic activity in calcium oxalate urolithiasis rats. Methods: The 75 male adult rats were random divided into five groups: negative control group rats were administered with common forage, positive control group rats were administered with high fat forage , stone group rats were administered with high fat diet and drinking 1% of ethylene glycol plus 1% of muriate water, perilla frutescens (L·) Britt·oil group rats were administered with high fat diet and drinking 1% of ehtylene glycol plus 1% of muriate water, meanwhil, tube feeding with perilla frutescens (L·) Britt·oil (10 g·kg-1·d-1) and sunflower seeds oil group rats were administered with high fat diet and drinking 1% of ehtylene glycol plus 1% of muriate water, and tube feeding with sunflower seeds oil (10 g·kg-1·d-1). 8 weeks later, serum cholesterol (TC), the triglyceride (TG) and tissue type plasminogen activator(tPA) were detected and compared with. Results: Perilla frutescens (L·) Britt·oil group and sunflower seeds oil group rats, the serum cholesterol and the triglyceride were signficantly lower than stone group(P<0.05~0.01). Stone group tissue type plasminogen activator were significantly lower compared with negative control group and perilla frutescens (L·) Britt·oil group(P<0.01). Conclusions: Urinary fibrinolytic activity was a important protective factor of urinary calculi formation, αLinolenic acid may prevent calcium oxalate urolithiasis formation by increasing urinary fibrinolytic activity. ......

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