[摘要] 目的 观察茶多酚对衰老小鼠红细胞氧化损伤的影响。 方法 对以D-半乳糖诱导衰老小鼠模型分 别以低、中、高剂量的茶多酚灌胃30 d，测定小鼠红细胞超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量，红细胞膜Na+-K+-ATPase活性和唾液酸含量。结果 模型组红细胞SOD活性、Na+-K+-ATPase活性和唾液酸含量与正常对照组比较显著下降，茶多酚给药组小鼠红细胞SOD活性、细胞膜Na+-K+-ATPase活性和唾液酸含量较正常对照组明显增高，MDA含量降低，在各给药组中以茶多酚大剂量组的作用最强。结论茶多酚能增强机体抗氧化能力，减少自由基对生物膜的损伤，维持细胞膜的稳定性，具有抗衰老作用。

    [关键词]茶多酚;衰老;红细胞;超氧化物歧化酶;丙二醛

    EFFECT OF TEA POLYPHENOL ON RED BLOOD CELLS OF AGING MICE INDUCED BY D-GALACTOSE

    WANG ZHEN-LI，CHEN XUE-HONG， WANG LI-HUA， et al

    (Department of Pharmacology， The First Sanatorium of Ji′nan Military Command in Qingdao， Qingdao 266071，China)

    [ABSTRACT]Objective To investigate the effect and mechanism of tea polyphenol on red blood cells (RBC) in aging mice. Methods The aging mice induced by D-galactose were given tea polyphenol at different doses for 30 days. The activity of SOD and the MDA content in RBC，the activity of Na+-K+-ATPase and content of acetylneuraminic acid in RBC membrane were detected. Results Comparing with normal control group ......