[摘要]目的 研究同种异体脂肪组织提取液对大鼠皮肤创面愈合的影响。方法 18只大鼠随机分成3组，在每只大鼠背部制备2个全层皮肤缺损创面，脂肪组织提取液组用同种异体脂肪组织提取液0.2 mL，基质对照组用磷酸盐缓冲液(PBS)0.2 mL，分别滴于创面，每天1次;空白对照组不滴加任何制剂。采用创面面积、伤腔容积和组织学指标评价创面愈合效果。结果 伤后7 d脂肪组织提取液组创面面积和伤腔容积均明显小于基质对照组和空白对照组( F= 105.51、8.67，q=4.29～18.71，P <0.05)。组织学检查显示脂肪组织提取液组创面肉芽组织和新生表皮生长明显。伤后14 d脂肪组织提取液组创面愈合情况优于基质对照组和空白对照组( F=96.47，q= 17.73 、16.82，P <0.05)。结论 同种异体脂肪组织提取液可加快大鼠皮肤创面愈合的速度，改善愈合质量。

     [关键词] 脂肪组织;组织提取物;皮肤损伤;伤口愈合

    EFFECTS OF HOMOLOGOUS ADIPOSE TISSUE EXTRACTS ON WOUND HEALING IN RATS

    ZHANG AN-YUAN， LI HAI-HONG， WANG JUN

    (Department of Pathology， No. 304 Hospital of PLA， Beijing 100037， China)

    [ABSTRACT]ObjectiveTo explore the effects of homologous adipose tissue extracts on wound healing after skin injury in rats. MethodsEighteen Wistar rats were randomly divided into three groups， namely adipose tissue extracts-treated group， PBS control group， and blank control group. Full-thickness wounds were made on the back of the rats (two wounds for each rat) followed by the above treatment once a day. Wound areas and volumes ......