结直肠癌_____结直肠癌;_溃疡性结肠炎;

溃疡性结肠炎与结直肠癌中MUC2、p53、PCNA的表达及临床意义

http://www.100md.com 《新疆医科大学学报》 2006年第5期

结直肠癌,,结直肠癌;,溃疡性结肠炎;,粘蛋白2;,p53;,增殖细胞核抗原,摘要,关键词,1资料与方法,2结果,3讨论,参考

     摘要：目的：探讨溃疡性结肠炎(UC)与结直肠癌(CRC)组织中粘蛋白2(MUC2)、p53和增殖细胞核抗原(PCNA)3种标记物的表达，为UC癌变的诊治提供依据。方法：采用免疫组织化学Evision二步法，对71例UC和59例CRC病检组织中MUC2、p53和PCNA 3种标记物的表达进行检测。结果：(1) UC、CRC组织中MUC2阳性表达率分别为97.19%、81.03%，p53阳性表达率分别为6.67%、45.76%，PCNA阳性表达率分别为74.24%、96.55%，UC和CRC组织中各标记物阳性表达率差异均有统计学意义(P<0.05)。(2)在CRC组织中，MUC2和p53的表达有一定关系，MUC2阳性表达的组织，p53多呈阴性表达；MUC2阴性表达的组织，p53多呈阳性表达(P<0.05)。(3) p53和PCNA也有一定关系，p53阳性表达的组织，PCNA多呈阳性表达；p53阴性表达的组织，PCNA多呈阴性表达(P<0.05)。(4) MUC2与PCNA的表达无明显关系(P>0.05)。结论：MUC2表达下调和p53、PCNA高表达可能与UC癌变的发生有关。

    关键词：结直肠癌; 溃疡性结肠炎; 粘蛋白2; p53; 增殖细胞核抗原

    Expression of MUC2, p53 and PCNA in UC and colorectal carcinoma tissue

    ZHANG Yongping, CAI Tingting, WANG Li

    (Department of Pathology, First Affiliated Hospital, Xinjiang Medical University,

    Urumqi 830000, China)

    Abstract: Objective: To study the expression of mucin 2 (MUC2), p53 and proliferating cell neuclear antigen (PCNA) in ulcerative colitis (UC) and colorectal carcinoma (CRC) tissue, to find the evidence of colorectal carcinogenesis from UC. Methods: Expression of MUC2, p53 and PCNA were detected by immunohistochemistry (Evision) in the tissue of 71 UC and 59 CRC specimens. Results: In the tissue of UC and CRC, the positive expression of MUC2 were 97.19%, 81.03%; p53 were 6.67%, 45.76%; PCNA were 74.24%, 96.55% respectively. These differences all had signification (P<0.05). In the tissue of CRC, MUC2 had relation to p53: the tissue of positive expression of MUC2, the expression of p53 was often negative; the tissue of negative expression of MUC2, the expression of p53 was often positive (P<0.05). p53 also had relation to PCNA: the tissue of positive expression of p53, the expression of PCNA was often positive; the tissue of negative expression of p53, the expression of PCNA was often negative (P<0.05). MUC2 showed no relation to PCNA (P>0.05). Conclusion: The downregulaed expression of MUC2 and the upregulated expession of p53 and PCNA may show signification in colorectal carcinogenesis from UC. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/06/10/00/87/14.htm

您现在查看是摘要页，全文长 7817 字符。