【摘要】 目的 探讨C—反应蛋白(CRP)水平在不同类型脑梗死(ACI)患者血清中的变化规律及其临床意义。方法 采用免疫比浊法对我院123例住院患者(发病1周内)进行CRP水平的测定，其中大动脉粥样硬化脑梗死(LAA)组28例、小动脉闭塞性脑梗死(SAO)组30例、心源性栓塞性脑梗死(CE)组11例、其他病因明确性脑梗死(OC)组37例、不明病因性脑梗死(UE)组17例，健康人群(JKR)组40例，并进行对照分析。结果 以CO中毒为主要危险因素组，其CRP增高率最高(本实验中为90%)，CRP水平也为最高，其次为冠心病组，高血压组与糖尿病组之间对比，无论是从增高率，还是从CRP水平方面，均无明显差异。结论 血清CRP可能在ACI患者的发生、发展中起一定作用，且其水平随卒中类型的不同而变化。

     【关键词】 脑梗死；C—反应蛋白

    The clinical significance of serum C-reactive protein (CRP) in patients with different types of acute cerebral infarction (ACI)

    GUO Mei-zhen.Department of Medical Laboratory Science, The Second Hospital of Zhuzhou, Hunan 412005,China

    【Abstract】 Objective To investigate the regularity of fluctuation and clinical senses of serum c-reactive protein(CRP) level in patients with acute cerebral infarction(ACI).Methods 123 subjects(68 males and 55 females) were divided into six groups including 28 large artery arteriosclerosis(LAA), 30 small artery occlusion(SAO), 11 cardiac embolism(CE), 37 other certain(OC) 、 17 undetermined etiology(UE)and 40 healthy, according to Trial of ORG 10172 in Acute Stroke Treatment(TOAST),through immune method, we detected and analyzed CRP levels of 123 inpatients.Results The risk factors of stroke included coronary artery disease, hypertension, diabetes and intoxication 0f CO and so on. Among the above-mentioned, the level of CRP and rate of increasing CRP of patients who poisoned by CO was the highiest.That of coronary artery disease group was lower. However, there was no notable difference between hypertension and diabetes groups.Conclusion CRP may play a certain role in the occurrence and development of ACI. It represents different levels in different types of stroke. ......