阿魏酸_____阿魏酸；合成方法；制备

阿魏酸的合成研究

http://www.100md.com 《广东药学院学报》 2001年第2期

阿魏酸,,阿魏酸；合成方法；制备,1材料与方法,2实验结果与讨论,3讨论,参考文献

     摘要以香草醛、丙二酸为原料，用哌啶作催化剂合成阿魏酸。实验结果表明：用苯作带水剂除去反应过程中形成的水，可大大提高反应产率。经HPLC跟踪，反应6 h后发现香草醛转化率达到98%以上，产物阿魏酸的收率为95%，纯度达到994%。

    关键词阿魏酸；合成方法；制备

    Study of the synthesis of ferulic acid

    ZHANG Xiangnian,XIANG Jun,JI Bo,ZHAO Shujin

    (Department of Pharmacology, Gaugnzhou General Hospital of Guangzhou Military Command,Guangzhou,Guangdong 510010)

    Abstract:Objective:To explore the synthesis of ferulic acid from vanillin,malonic acid and piperidine. Methods:Addition to pyridine as a solvent,benzene was added to the reactants mixture,at refluxing temperature,it formed azotropic with water,and the water produced during the reaction was separated off. By this way ferulic acid yield was greatly increased. Results:Under this reaction condition,vanillin was almost changed into ferulic acid,with the yield as high as 95% and the purity 99.4%. Conclusion:This improved method was more suitable to produce ferulic acid in large scale.

    Key words ferulic acid;synthetic method;preparation

    阿魏酸是常用中药川芎中的主要酸性成分 ......

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