摘要 :目的 测定子宫内膜癌组织中微血管密度(MVD)表达情况，探讨MVD与子宫内膜癌的临床病理特征、转移、预后的关系。 方法 选取47例子宫内膜癌标本，采用免疫组织化学技术利用Ⅷ因子相关抗原标记癌组织中的血管内皮细胞，高倍镜下计数为MVD。与20例正常子宫内膜标本进行对照。 结果 ①子宫内膜癌组织的MVD值均高于正常子宫内膜(P<0.01)，且绝经后内膜癌患者的MVD高于绝经前患者(P<0.05)。②MVD与子宫内膜癌患者的年龄、组织学分级、FIGO分期、子宫肌层浸润深度及淋巴结转移相关(P<0.01、P<0.05)。③FI-GO分期越晚，MVD越呈高密度表达趋势，两者之间有相关性(P<0.01)，微血管高密度表达患者预后差(P<0.05)。 结论 MVD与子宫内膜癌恶性程度和浸润转移密切相关，是临床判断预后的重要指标。

    关键词 :子宫内膜癌;血管生成;微血管密度;免疫组织化学;临床病理因素;预后

    Clinical significance of MVD in endometrial carcinoma

    WANG Wei，YAN li

    (Department of Obstetrics and Gynecology，Shenzhen Nanshan Material and Child Health Hospital，Shenzhen，Guangdong518052，China)

    Abstract:Objective Microvessel density(MVD)was studied to decipher its value in the clinical pathology，metastasis and prognosis of endometrial carcinoma.Methods Microscopic sections from47specimens of endometrial carcinoma were scanned at low magnification to identify areas of top capillary density，and the parallel sections were then stained immunohisto-chemically with a marker for endothelial cells to determine the microvascular density(MVD)in terms of the number of vessels per high-power microscopic field.Twenty samples of normal endometriumwere used for control.Results ①The MVD in en-dometrial carcinoma was higher than in normal endometria(P<0.01) ......