VEGF在大鼠慢性酒精性肝损伤中的表达
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李伟平, 任浩洋, 张宝阳, 虞朝辉, 厉有名
血管内皮生长因子;酒精性肝病;逆转录聚合酶链反应李伟平,任浩洋,张宝阳,虞朝辉,厉有名.VEGF在大鼠慢性酒精性肝损伤中的表达. 世界华人消化杂志2006;14(18)1766-1770&
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李伟平, 张宝阳, 浙江省湖州市中心医院消化科 浙江省湖州市 313000
任浩洋, 解放军总医院西院药局 北京市 100853
虞朝辉, 厉有名, 浙江大学医学院附属第一医院消化科 浙江省杭州市 310009
李伟平, 1982年毕业于浙江大学医学院附属第一医院, 副主任医师, 主要从事消化系统疾病的研究.
通讯作者: 厉有名, 310009, 浙江省杭州市庆春路79号, 浙江大学医学院附属第一医院消化科. zlym@zju.edu.cn
收稿日期: 2006-04-13 接受日期: 2006-05-25
Expression of vascular endothelial growth factor in chronic alcoholic liver fibrosis in rats
Wei-Ping Li, Hao-Yang Ren, Bao-Yang Zhang, Chao-Hui Yu, You-Ming Li
Wei-Ping Li, Bao-Yang Zhang, Department of Digestive Diseases, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, China
Hao-Yang Ren, General Hospital of Chinese PLA, 100853 Beijing, China
Chao-Hui Yu, You-Ming Li, Department of Digestive Diseases, the First Hospital of Zhejiang University Medical College, Hangzhou 310009, Zhejiang Province, China
Correspondence to: You-Ming Li, Department of Digestive Diseases, the First Hospital of Zhejiang University Medical College, Hangzhou 310009, Zhejiang Province, China. zlym@zju.edu.cn
Received: 2006-04-13 Accepted: 2006-05-25
Abstract
AIM: To investigate the expression of vascular endothelial growth factor (VEGF) and its role in the pathogenesis and development of chronic alcoholic liver fibrosis in rats.
METHODS: Liver fibrosis models were established in 24 SD rats by intragastric administration (7 g/kg) of alcohol (56º, 560 mL/L) every morning, and 10 normal rats served as controls. The rats in model group were killed by exsanguination from femoral vein at 4, 12 and 24 wk. Pathological changes of liver tissues in rats were identified by Masson staining, and the expression of VEGF mRNA was detected by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) ......
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