5-羟色胺转运体基因多态性与肠易激综合征的相关性
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张晓敏, 林志辉
肠易激综合征;5-羟色胺转运体;基因多态性张晓敏,林志辉.5-羟色胺转运体基因多态性与肠易激综合征的相关性. 世界华人消化杂志2006;14(18)1790-1794,5-羟色胺转运体基因
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张晓敏, 林志辉, 福建医科大学省立临床学院胃肠病研究所 福建省福州市 350001
张晓敏, 福建医科大学2003届硕士研究生, 主要从事功能性肠病的研究.
通讯作者: 张晓敏, 350001, 福建省福州市东街134号, 福建省立医院胃肠病研究所. 07091980557@sina.com.cn
电话: 0591-87699780
收稿日期: 2006-04-11 接受日期: 2006-04-29
Relationship between serotonin transporter gene polymorphism and irritable bowel syndrome
Xiao-Min Zhang, Zhi-Hui Lin
Xiao-Min Zhang, Zhi-Hui Lin, Institute of Gastrointestinal Diseases, Fujian Provincial Clinical College of Fujian Medical University, Fuzhou 350001, Fujian Province, China
Correspondence to: Xiao-Min Zhang, Institute of Gastrointestinal Diseases, Fujian Provincial Hospital, Fuzhou 350001, Fujian Province, China. 07091980557@sina.com.cn
Received: 2006-04-11 Accepted: 2006-04-29
Abstract
AIM:To investigate the relationship between serotonin transporter gene polymorphism and irritable bowel syndrome (IBS).
METHODS:Polymerase chain reaction (PCR) was used to comparatively analyze the polymorphisms of serotonin transporter gene 5-HTTLPR and VNTRs within intron 2 in patients with diarrhea-predominant IBS (D-IBS,n = 51), constipation-predominant IBS (C-IBS, n = 58), and alternating diarrhea and constipation IBC (A-IBS, n = 38) and healthy controls (n = 48).
RESULTS:The frequencies of L/L genotype and L allele in C-IBS patients were significantly higher than those in the controls (31.0% vs 8.3%, c2 = 8.229, P < 0.05; 47.4% vs 29.2%, c2 = 7.342, P < 0.05). The frequencies of S/S genotype and S allele in D-IBS patients were significantly higher than those in C-IBS and A-IBS patients (S/S: 56.9% vs 36.2%, 36.8%, P < 0.05; S: 71.6% vs 52.6%, 56.6%, P < 0.05), but the frequency of L/L genotype was markedly lower (9.8% vs 31.0%, 23.7%, P < 0.05). However, no significant difference was found in VNTRs polymorphism between the subgroups of IBS and controls (P > 0.05).
CONCLUSION: The presence of L/L genotype and L allele probably increases the susceptibility of individuals to C-IBS, while S/S genotype and S allele probably increases that to D-IBS ......
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