摘要:目的 探讨子痫前期患者红细胞膜钠钾ATP酶(NKA)活性及脂质过氧化反应的变化及他们在疾病中的作用。 方法 检测45例子痫前期患者红细胞膜钠钾ATP酶(NKA)活性及血清脂质过氧化产物丙二醛(MDA)的水平。 结果 与正常妊娠孕妇相比，子痫前期患者红细胞膜钠钾ATP酶活性明显降低，血清MDA水平明显升高。在子痫前期患者中，胎儿宫内生长受限组较非胎儿宫内生长受限组红细胞膜钠钾ATP酶活性明显降低。子痫前期患者组红细胞膜钠钾ATP酶活性与血清MDA呈负相关。 结论 细胞膜钠钾ATP酶活性下降参与了妊高征的发生发展，且可能影响胎儿的营养供应。细胞膜钠钾ATP酶活性下降与脂质过氧化代谢有密切关系。

     关键词:子痫前期;钠钾ATP酶;脂质过氧化;红细胞;丙二醛

    The relationship between the activity of Na + &K + ATPase and lipid peroxidation in preeclampsia patients.

    YANG Shang-wu，GOU Wen-li，WEN Meng-ling.

    (Shenzhen Municipal Maternal Hospital，Shenzhen518028，Guangdong，P.R.China)

    Abstract:Objective To investigate the activity of erythrocyte membrane Na + /K + ATPase and peroxidation in preeclampsia. Methods The activity of erythrocyte membrane Na + /K + ATPase and serum peroxidation products in45cases of preeclampsia were tested. Results The activity of erythrocyte membrane Na + /K + ATPase was much lower and serum peroxidation products much higher in preeclampsia patients than that of normal pregnancy;there was negative correlation between the activity of erythrocyte membrane Na + /K + ATPase and serum peroxidation products MDA in preeclampsia. Conclusion The delined activity of erythro-cyte membrane Na + /K + ATPase may contribute to the development of preeclampsia and impair nutritional supply of fetus.the delined activity of erythrocyte membrane Na + /K + ATPase in preeclampsia may be due to increase of serum peroxidation products. ......