摘要:目的 研究多肿瘤标志物蛋白芯片检测系统对肺癌的诊断价值。 方法 用多肿瘤标志物蛋白芯片检测系统测定分析116例肺癌患者，42例肺良性疾病患者和165例正常人血清中肿瘤标志物(CA199、NSE、CEA、CA242、CA125、CA153、AFP、Fe、f-PSA、PSA、β-HCG、HGH)的水平。 结果 116例肺癌患者有88例血清肿瘤标志物为阳性，阳性率为75.9%;42例肺良性疾病患者有7例血清肿瘤标志物为阳性，阳性率为16.7%;165例正常人血清中没有发现阳性。 结论 多肿瘤标志物蛋白芯片检测系统的应用对肺癌的诊断有较高的临床参考价值。

    关键词:肺癌;肿瘤标志物;蛋白芯片

    The diagnostic value of multiple tumor markers detection protein chip in diagnosis of lung cancer.

    ZHENG San.

    (Labo-ratory Department of Affiliated Hospital of Hainan Medical College，Haikou570102，Hainan，P.R.China)

    Abstract:Objective To assess the value of multi-tumor marker protein biochip detective system in diagnosis of lung cancer. Methods The levels of12tumor markers(CA199，NSE，CEA，CA242，CA125，CA153，AFP，Fe，f-PSA，PSA，B-HCG，HGH)in sera of116lung cancer patients，42patients with benign pulmonary disease and165normal persons were determined，ana-lyzed by using multi-tumor markers protein biochip detective system. Results At least one kind of tumor marker was found higher in88sera of the116lung cancer patients with a positive rate of75.9%.Seven sera of42patients with benign pulmonary disease positive with a positive rate of16.7%.No tumor markers were observed in165normal persons. Conclusion Multi-tumor mark-er protein biochip detective system possesses clinical reference value in diagnosis of lung caner. ......