颈动脉粥样硬化患者血管内皮功能及普罗布考干预研究
动脉硬化；,颈动脉；,内皮,血管；,老年人,1资料与方法,2结果,3讨论
【摘要】 目的 了解老年颈动脉粥样硬化患者肱动脉内皮依赖性舒张功能(即血流介导的血管扩张功能，flowmediated dilation,FMD)、硝酸甘油介导的非内皮依赖性舒张功能(nitroglycerinmediated dilation,NMD)、血浆血管内皮活性因子一氧化氮(NO)、内皮素(ET)的水平以及普罗布考对上述指标及血清总胆固醇(TC)水平的影响。 方法 分别于口服普罗布考(05g，每日2次，持续12周)前后检测43例老年颈动脉粥样硬化患者肱动脉的FMD及NMD；同时测定NO、ET和TC水平，并与40例健康老人进行对照研究。 结果 老年颈动脉粥样硬化患者肱动脉的FMD及NMD均显著低于健康老年组(P<005)，NO水平显著低于健康老年组，而ET却显著高于健康老年组；老年颈动脉粥样硬化组口服普罗布考12周后的FMD和NMD较治疗前显著升高(P<005)，TC水平显著降低(P<005)，NO水平显著升高，ET水平显著降低(P<005)。 结论 (1)老年颈动脉粥样硬化患者肱动脉FMD及NMD均受损；(2)老年颈动脉粥样硬化患者存在血管内皮功能失调；(3)普罗布考能降低老年颈动脉粥样硬化患者的胆固醇水平，改善血管内皮功能。【主题词】 动脉硬化； 颈动脉； 内皮，血管； 老年人
Investigation on the vascular endothelial function of the patients with carotid atherosclerosis and on the intervention effect of probucol CHEN Deyou, FAN Li，LIU Tao The Outpatient Department of Chinese PLA General Hospital, Beijing 100853 China
【Abstract】 Objective To evaluate the vascular endothelial function of the old patients with carotid atherosclerosis and the effect of probucol on the vascular endothelial function and the total cholesterol level Methods Before and after oral administration of probucol,the endotheliumdependent (ie flowmediated dilation,FMD)and endotheliumindependent dilation(ienitroglycerinmediated dilation,NMD)of the 43 old patients with carotid atherosclerosis were detected and compared with 40 old healthy controlsMeanwhile, the plasma level of nitrix oxide(NO) and endothelin(ET) was examined Results (1)Both FMD and NMD of the brachial artery in the old patients with carotid atherosclerosis were less than those of the controls significantly(P<005) (2)The plasma concentration of NO of the old patients with carotid atherosclerosis was lower than that of the controls ......
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