摘要:目的 探讨HBV各基因型与DNA水平及HBeAg关系，分析不同基因型引起不同的临床表现。 方法 对108例HBV-DNA阳性患者进行基因分型、HBV-DNA定量检测、ELISA法检测HBeAg及肝功能检查后综合分析。 结果 基因分型为B型29例，C型51例，混合型16例，D型4例和未分型8例;C型HBV-DNA水平和HBeAg阳性率分别为(6.87±1.55)log值和74.51%，明显高于B型的(5.32±1.04)log值和44.83%(P<0.01);C型发展为慢性乙型肝炎(CHB)、肝硬化(LC)和原发性肝细胞癌(HCC)分别为49.0%、17.6%、13.7%，明显高于B型的41.4%、6.9%和3.4%(P<0.05);乙型肝炎病人中C型ALT、AST、TBIL和γG水平及发病年龄等均高于B型(P<0.05)。 结论 广州地区HBV基因型以C型为主，B型次之。C型HBV-DNA水平显著高于B型，B基因型HBeAg阳性率较C基因型高。C型肝脏损害比B型严重。

     关键词:肝炎病毒，;乙型;基因分型;HBV-DNA;HBeAg

    Investigation of the relationship of hepatitis B virus gene type and HBV-DNA level with clinical manifestations.

    OU Ying-yan，YANG Hai-hong，ZENG Wen-ting，et al.

    (Division of Infection of First Affiliated Hospital of Guangzhou Medical College，Guangzhou510120，Guangdong，P.R.China)

    Abstract:Objective To investigate the relationship between hepatitis B virus genotype and serum level of HBVDNA and HBeAg.analyze different HBV genotype leading to the change of clinical manifestations. Methods The genotype of HBV and serum level of HBVDNA in108patients positive for HBV DNA were determined.ELISA was used for detection of HbeAg and liver function was also examined. Results 29patients were differentiated as genotype B ......