老年急性冠脉综合征患者血清可溶性Fas变化及意义
冠状动脉疾病；,肌钙蛋白I；,老年人,1资料与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨老年急性冠脉综合征(ACS)患者血清中可溶性Fas(sFas)的变化及意义。 方法 应用酶联免疫吸附双抗体夹心(ABCELISA)法，测定40例老年ACS患者[包括14例不稳定型心绞痛(UAP)、26例急性心肌梗死(AMI)]和17例对照组受试者血清sFas 的水平，其中ACS患者同时应用该方法进行血清肌钙蛋白I(cTnI)定量检测。 结果 AMI组和UAP组血清sFas水平均明显高于对照组(P<005)，ACS患者中cTnI升高组与正常组血清sFas水平差异无显著性(P>005)。 结论 高水平的血清sFas可能与ACS有关，血清sFas水平的变化早于cTnI的变化，可作为判断动脉粥样硬化斑块稳定性的指标。【主题词】 冠状动脉疾病； 肌钙蛋白I； 老年人
Serum levels of soluble Fas in elderly patients with acute coronary syndrome HU Sigan,CAI Xin，GAO Dasheng,ZHANG Heng,SHI Xiaojun,WANG Hongju. Department of Cardiovasology， Affiliated Hospital，Bengbu Medical College,Bengbu 233004 China
【Abstract】 Objective To explore the variation and clinical significance of serum levels of soluble Fas (sFas) in elderly patients with acute coronary syndrome (ACS). Methods By enzymelinked immunosorbent assay (ELISA), serum sFas was measured in 40 elderly patients with ACS [including 14 unstable angina pectoris (UAP) and 26 acute coronary myocardial infarction (AMI)] and 17 subjects without coronary heart disease.Forty patients with ACS underwent the measurement of cardiac tropnin I (cTnI). Results Mean level of sFas was significantly higher in patients with AMI than that in controls (P<005).Mean level of sFas was also significantly higher in patients with UAP than that in controls(P<005) No difference was found in patients with ACS with increased cTnI or without (P>005). Conclusions High serum levels of sFas may have relationship with ACS The serum level of sFas changed before the variation of cTnI.Therefore ......
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