摘要：目的：探讨用乙肝免疫球蛋白经母体对胎儿进行被动免疫，阻断乙肝病毒母婴宫内感染的疗效。方法：将100例血清乙型肝炎表面抗原HBsAg阳性的孕妇随机分为两组：乙肝免疫球蛋白(HBIG)组50例，分别在孕28、32、36周各肌注乙肝免疫球蛋白200IU一次；对照组50例，未予用药。分娩后采集两组新生儿脐血，分离血清，用ELISA法和荧光定量PCR法检测乙肝表面抗原HBsAg、乙肝e抗原HBeAg。结果：乙肝免疫球蛋白(HBIG)组和对照组宫内感染率分别为10%、23.7%，差异有统计学意义(P<0.05)。结论 ：对乙肝表面抗原HBsAg孕妇产前多次肌注HBIG可以有效降低HBV宫内感染率。

     关键词：乙型肝炎免疫球蛋白；宫内感染

    The Clinical Observation on the Effect of Hepatitis B Immunoglobulin on the Interruption of Hepatitis B Virus Intrauterine Infection

    CHEN Qiu-mei,CHEN Wen

    (The Second People's Hospital of Shantou City, Guangdong Shantou 515031,China)

    Abstract：Objective: To explore the effectiveness of hepatitis B immunoglobulin on interrupting hepatitis B virus intrauterine infection with passive immunization from mother to infant. Method: One hurdred cases of HbsAg positive pregnant women were randomly allocated to two groups, of 50 women were allocated to trial groups, and injected with 200 IU of hepatitis B immunoglobulin for 1 injection at the 28th ,32th and 36th weeks of pregnancy respectively, 50 women in the control group received no treatment. The samples of cord blood from the newborns in two groups were collected and tested for HBsAg and HBeAg by ELISA and FQ—PCR. Result : The intrauterine infection rate in HBIg group and control group were 10% and 23.7%,respectively,with significant difference (P<0.05). Conclusion: HBIG can significantly decrease the HBV intrauterine infection rate when administered to pregnant women of HBsAg positive regularly during late pregnancy. ......