摘要:弹性蛋白酶是炎症过程中由分叶核中性粒细胞分泌的一种蛋白酶，其抑制剂结合物Ela/α1-PI被认为是男性隐匿性生殖道炎症标记物。应用酶联免疫分析技术检测精浆中的Ela/α1-PI，发现不育症组男性精液中的Ela/α1-PI水平明显高于有生育组。高水平的Ela/α1-PI与女性配偶输卵管损伤相关，抗生素治疗后，可以观察到Ela/α1-PI水平降低。但女性配偶输卵管损伤对抗生素治疗不敏感。除了诊断男性不育症之外，检测Ela/α1-PI还能帮助诊断前列腺及其他附性腺器官细菌性炎症。精浆Ela/α1-PI检测是一种易操作、可靠、定量的试验，可以用来诊断夫妇双方生殖道炎症及判断预后，而且，连续检测可以动态监测疗效。

    关键词:精浆;弹性蛋白酶及酶抑制剂结合物Ela/α1-PI;男性不育症;生殖道炎症

    The detection and clinical application of granulocyte elastase in seminal plasma.

    WEI Xiao-bin，BAI Zhi-ming.

    (Haik-ou Municipal People's Hospital，Haikou570208，Hainan，P.R.China)

    Abstract:Elastase is a protease released by polymorphonuclear neutrophils during the inflammatory process.seminal elastase-inhibitor complex(Ela/α1-PI)has been proposed as a marker of male silent genital tract inflammation.Measured by immunoassay in seminal plasma，Ela/α1-PI，is useful in the detection of genital tract inflammation.The prevalence of increased seminal Ela/α1-PI in infertile men is significantly higher than that observed in fertile men.Ela/α1-PI level is significantly associated with tubal damage in female partners.After antibiotic therapy ......