摘要:目的 探讨脑脊液腺苷脱氨酶(ADA)测定对小儿结核性脑膜炎诊断的临床意义。 方法 对确诊的37例结核性脑膜炎、38例化脓性脑膜炎、40例病毒性脑炎及40例非脑炎患儿采用全自动生化分析仪检测脑脊液ADA。 结果 结核性脑膜炎患儿脑脊液ADA明显高于其它各组，差异有统计学意义。以ADA>8U/L作为阳性阈值，诊断结核性脑膜炎的敏感度、特异度、准确度、阳性预测值、阴性预测值分别为81.1%、98.3%、94.2%、93.8%、94.4%。 结论 脑脊液腺苷脱氨酶可作为诊断小儿结核性脑膜炎的重要参考指标。

    关键词:儿童;结核性脑膜炎;腺苷脱氨酶

    The significance of determination of adenosine deaminase in diagnosis of cerebrospinal fluid from infantile tuberculous meningitis patients.

    CHEN Guang-bin，PANG Wei-jun，LU Xian.

    (Affiliated Hospital of Guangdong Medical College，Zhan-jiang524001，Guangdong，P.R.China)

    Abstract:Objective To investigate the clinical significance of determination of adenosine deaminase(ADA)from cerebrospinal fluid in diagnosis of infantile tuberculous meningitis patients. Methods The activity of ADA in cerebrospinal fluid of37patients with tuberculous meningitis ......