【摘要】 目的 探索Calpain10基因SNP43及部分环境因素对新疆地区维吾尔族T2DM易感性的影响。 方法 采用ARMS-PCR对54例T2DM患者和107例NGT人群Calpain10基因SNP43进行基因分型，并对部分环境因素进行logistic逐步回归分析。 结果 ①与NGT组相比，SNP43的A等位基因频率升高。②文化程度高、动物内脏摄入量大、血胆固醇高与T2DM的发生呈正相关，而饮茶、水果摄入适中与其呈负相关。 结论 Calpain-10SNP43A等位基因可能与维吾尔族T2DM相关。文化程度高、动物内脏摄入量大、血胆固醇高等因素是维吾尔族T2DM发生的危险因素，饮茶、适量水果摄入是其发生的保护因素。

     【关键词】 环境;维吾尔族;糖尿病，非胰岛素依赖型

    Calpain10genetype of type2diabetes mellitus and environmental factors in Xinjiang Uygur population

    LI Lin-lin，ZHANG Yue-ming，DU Jing-yu，MAO Xin-min，RAN Xin-jian ，WANG Chang-hui，LI Nian-dong，SUN Xiao-feng ，LIN Ren-yong ，YANG Yong-xin .

    1.Department of Phar-macology，Xinjiang Medical University，Urumuqi 830054，China;

    2.Department of Nutrition，Xinjiang Medical University，Urumuqi 830054，China;

    3.Department of Energy Center，Xin-jiang Medical University，Urumuqi 830054，China;

    4.Department of Stomatology，General Hos-pital of Xinjiang Military，Urumuqi 830000，China;

    5.The First Affiliated Hospital of Xinjiang Medical University，Urumuqi 830091，China

    【Abstract】 Objective To explore the effect of single nucleotide polymorphism43(SNP43)of Calpain10gene and part of environmental factors on T2DM in Xinjiang Uygur population.Methods The study samples consisted of107NGT and54T2DM of Uygur subjects.ARMS-PCR was used to determine the distribution of genotype and allele frequencies of SNP43polymorphism(G/A).The relationship between environmental factors and T2DM was analyzed by logistic stepwise regression.Results ①The frequen-cies of“A”allele was significantly increased as compared with that in NGT subjects.②Higher education level ......