【摘要】 该文主要介绍膳食叶酸摄入不足对血浆同型半胱氨酸(homocysteine，Hcy)水平的影响，并总结了机体叶酸缺乏及Hcy水平过高与高血压、心血管疾病、脑血管疾病、外周血管疾病及先天性血管缺陷的关联。同时，从内皮细胞NO合成、氧化应激、炎症反应、脂质代谢、凝血系统-抗凝系统、血管平滑肌细胞增殖等角度分别阐述了两者导致血管病发生、发展的可能机制。

     【关键词】 叶酸;同型半胱氨酸;血管病

    Effect and mechanism of folic acid and Hcy on vascular diseases

    LI Dan，WU Kun.

    Department of Nutrition and Food Hygiene，Harbin Medical University，Harbin 150001，China

    【Abstract】 The paper describes the effect of folic acid insufficiency on serum Hcy concentration，and reviews the correlation between low folic acid level，hyperhomocysteinemia and vascular diseases includ-ing hypertension，cardiovascular disease，cerebral vascular disease，peripheral arterial disease and congen-ital vascular disease.Meanwhile，the possible mechanism is inferred from endothelial NO synthesis，ox-idative stress，inflammatory reaction，lipid metabolism，coagulation and anticoagulation system，vascular smooth muscle cells proliferation，etc.

    【Key words】 Folic acid;Cysteine;Vascular disease

    (Chin J Dis Control Prev2006，10(3):299-302)

    越来越多的流行病学、实验及临床证据显示机体叶酸水平与血管病的发生有关 ......