不同剂量氟西汀治疗首发抑郁症临床研究
氟西汀；剂量；抑郁症；汉密尔顿抑郁量表,,氟西汀；剂量；抑郁症；汉密尔顿抑郁量表,【摘要】,【关键词】,1对象与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨不同剂量氟西汀治疗首发抑郁症的疗效及不良反应。方法 将63例首发抑郁症患者随机分为A(18例)、B(28例)、C(17例)三组，分别给予氟西汀60mg·d-1、40mg·d-1和20mg·d-1治疗，疗程8w。采用汉密尔顿抑郁量表、副反应量表于治疗前及治疗2、4、6、8w末评定临床疗效和不良反应。 结果 三组汉密尔顿抑郁量表评分在治疗第2w末较治疗前显著下降；A、B组与C组在治疗第2w、4w末比较差异均有极显著性(P<0.01)，A、B组显效较C组快。副反应量表评分在治疗第2w、4w末A组与B、C组同期比较差异有显著性(P均<0.05)。结论 氟西汀治疗首发抑郁症的最有效剂量为40mg·d-1。【关键词】 氟西汀；剂量；抑郁症；汉密尔顿抑郁量表
Clinical studies of different doses of fluoxetine in the treatment of firstepisode depression.
Ning Nanyi，Zhang Haoying，Wang Shoumei，et al
(Fuyang Mental Hospital, 236015, Anhui, China)
【Abstract】 Objective To explore efficacy and side effects of different doses of fluoxetine in the treatment of firstepisode depression. Methods 63 patients with firstepisode depression were randomly assigned to group A(n=18,took fluoxetine 60mg/d), group B(n=28,40mg/d) and group C(n=17,20mg/d) for 8 weeks . Efficacy and side effects were assessed with the Hamilton Depression Scale(HAMD) and Treatment Emergent Symptom Scale(TESS) before treatment and at 2nd, 4th, 6th and 8th week of treatment. Results At the end of 2nd week, HAMD scores of the 3 groups decreased significantly compared with pretreatment; at the ends of 2nd and 4th week, group A and B worked faster than group C did and difference was most significant(P<0.01); at the ends of 2nd and 4th week, there were significant differences in the TESS scores between group A and group B or C( each P<0.05). Conclusion 40mg/d of fluoxetine is the best dose in treatment of firstepisods depression patients. ......
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