谷胱甘肽对奥沙利铂神经毒性的防治效果
谷胱甘肽；奥沙利铂；神经毒性；肝癌,,]谷胱甘肽；奥沙利铂；神经毒性；肝癌,1资料与方法,2结果,3讨论,参考文献
[摘要]目的评价谷胱甘肽对奥沙利铂神经毒性的防治效果。方法对70例应用奥沙利铂经动脉插管化疗治疗患者进行回顾性分析。预防治疗组：44例中，男36例，女8例；年龄22～75岁，平均年龄48岁。对照组：26例中，男20例，女6例；年龄19～70岁，平均年龄45岁；预防治疗组介入前2天开始使用还原型谷胱甘肽，每日1 200mg加入5%葡萄糖注射液250ml中静脉滴注，至介入后3～5天。对照组只予以保肝、对症治疗，不用谷胱甘肽。结果对照组奥沙利铂神经毒性的发生率为46.15%(12/26)，预防组13.64%(6/44),经χ2检验，差异有非常显著性(P<0.01)。结论谷胱甘肽对预防奥沙利铂的神经毒性有较好的治疗效果，是预防奥沙利铂的神经毒性主要措施之一。[关键词]谷胱甘肽；奥沙利铂；神经毒性；肝癌
The effect of reduced glutathione in preventing and treating neurotoxicity of oxaliplatin
CHEN Qingfeng, MA Aiying, WANG Haijie.
Department of liver cancer, the 445th Hospital of PLA, Shanghai 200052
[Abstract]ObjectiveTo evaluate the effect of reduced glutathione in preventing and treating neurotoxicity of oxaliplatin. Methods70 chemotherapy patients with oxaliplatin through arterial infusion were analyzed retrospectivly. Prevention and treatment group: 44 patients (36 males and 8 females in respectively) from 22~75 ages, the average age was 48. Control group: 26 patients (20 males and 6 females in respectively) from 19~70 ages, the average age was 45. Two days before intervention, prevention and treatment group received 250ml 5% glucose injection added with 1 200mg reduced glutathione intravenously every day untill to 3~5 days after intervention. Control group only received common treatments. ResultsThe generation rate of neurotoxicity in prevention and treatment group was 13.64% (6/44), 46.15% (12/26) in control group (P<001). ConclusionsThere is more effective outcome in using reduced glutathione to prevent and treat neurotoxicity of oxaliplatin, so using reduced glutathione is one of the methods to prevent and treat neurotoxicity of oxaliplatin. ......
您现在查看是摘要页，全文长 6847 字符。