乙型肝炎；干扰素α1b；细胞间粘附分子1；组织学

干扰素治疗前后慢性乙型肝炎患者的肝组织学观察

http://www.100md.com 《东南国防医药》 2004年第4期

乙型肝炎；干扰素α1b；细胞间粘附分子1；组织学,,]乙型肝炎；干扰素α1b；细胞间粘附分子1；组织学,1材料与方法,2结果,3讨论,参考文

     [摘要]目的探讨干扰素治疗前后，慢性乙型肝炎患者肝组织中细胞间粘附分子1(ICAM1)的表达与组织学变化。方法于干扰素治疗前1周内和治疗6个月结束后1周内，取36例慢性乙型肝炎患者的肝脏活检组织，评估肝组织学活动指数(HAI)，采用免疫组化SP法检测肝组织中ICAM1和HBsAg、HBcAg的表达情况。结果治疗后38.9%(14/36)的患者有应答反应，与治疗前相比干扰素治疗后慢性乙型肝炎患者肝组织学活动指数、ICAM1和HBcAg的表达均有明显下降(P<0.05)，无应答反应者与治疗前相比，上述3项指征均无明显变化(P>0.05)。结论干扰素治疗可调控细胞ICAM1的表达，抑制或减少肝细胞中HBV的复制及表达，进而改善肝组织炎症的活动程度。

    [关键词]乙型肝炎；干扰素α1b；细胞间粘附分子1；组织学

    Observation on the liver histology of the patients with chronic hepatitis B after interferon treatment

    ZHANG Minfeng, ZHENG Ruidan, GUO Yihe, et al.

    The 175th Hospital of PLA, Zhangzhou 363000, Fujian, China

    [Abstract]ObjectiveTo explore the expression of ICAM1 and histology change in liver tissues of the patients with chronic hepatitis B after interferon treatment. MethodsThirtysix patients with chronic hepatitis B were enrolled in this research. Liver biopsy was performed on each patient in one week before treatment and one week after six months' treatment respectively. The expressions of ICAM1, HBsAg and HBcAg were determined by SP immunohistochemistry, as well as liver histology activity index(HAI) was evaluated. ResultsThe patients responded to interferon accounted for 38.8% (14/36). Compared with pretreatment, the expressions of ICAM1 and HBcAg decreased significantly (P<0.05) after treatment, so did the HAI in liver. The expressions of ICAM1, HBcAg and the HAI had no apparent changes(P>0.05) compared with pretreatment. ConclusionsInterferon treatment can regulate the expression of ICAM1 in hepatocytes and inhibit or reduce the replication of HBV in liver. So we conclude interferon treatment can repress the inflammation activity degree of liver tissue in the patients with chronic hepatitis B. ......

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