帕罗西汀与氯硝西泮治疗广泛性焦虑症对照研究
帕罗西汀；氯硝西泮；广泛性焦虑症；焦虑自评量表；汉密顿焦虑量表,,帕罗西汀；氯硝西泮；广泛性焦虑症；焦虑自评量表；汉密顿焦虑量表,【摘要】,【关键词】
【摘要】 目的 探讨帕罗西汀与氯硝西泮治疗广泛性焦虑症的疗效与不良反应。方法 将63例广泛性焦虑障碍患者随机分为两组。研究组32例给予帕罗西汀治疗；对照组31例给予氯硝西泮治疗，两组疗程均为6w。两组于治疗前和治疗第3，6w末采用焦虑自评量表、汉密顿焦虑量表和副反应量表评定临床疗效与副反应,并进行比较。结果 帕罗西汀与氯硝西泮对广泛性焦虑障碍均有明显疗效。两组组内治疗前与治疗第3，6w末汉密顿焦虑量表、焦虑自评量表减分率比较有极显著性差异(P<0.01)；两组间汉密顿焦虑量表减分率比较无显著性差异(P>0.05)，焦虑自评量表减分率差异有极显著性(P<0.01)；治疗第6w末两组副反应量表评分有极显著性差异(P<0.01)。 结论 帕罗西汀治疗广泛性焦虑障碍安全有效，患者耐受性好，副反应轻微。【关键词】 帕罗西汀；氯硝西泮；广泛性焦虑症；焦虑自评量表；汉密顿焦虑量表
A controlled study of paroxetine and flunipam in the treatment of generalized anxiety
Peng Lifeng, Zhang Cun, Gong Yunqin
(Tengzhou Mental Hospital, 277500, Shandong, China)
【Abstract】 Objective To explore the efficacies and side effects of paroxetine and flunipam in the treatment of generalized anxiety. Methods 63 patients with generalized anxiety were randomly divided into research(n=32, took paroxetine) and control(n=32,did flunipam) group for 6 weeks. Efficacies and side effects were assessed and compared using the Selfrating Anxiety Scale(SAS), the Hamilton Anxiety Scale(HAMA) and the Treatment Emergent Symptom Scale(TESS) before treatment and at the ends of the 3rd and 6th week treatment. Results Both paroxetine and flunipam had better efficacies in the treatment of generalized anxiety.There were the most significant differences in scorereducing rates of the SAS and HAMA between pretreatment and ends of the 3rd and 6th week for both 2 groups(P<0.01); there was no significant differnce in scorereducing rate of the HAMA(P>0.05) and was the most significant difference in that of the SAS(P<0.01) between the 2 groups; at the end of the 6th week, there was the most significant differnce in the score of the TESS between the 2 groups(P<0.01).Conclusion Paroxetine is effective and safe and has well tolerance and milder side effects in the treatment of generalized anxiety. ......
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