子宫颈癌P_糖蛋白表达及其意义
子宫颈肿瘤；基因表达；P_糖蛋白；药物耐受性,,]子宫颈肿瘤；基因表达；P_糖蛋白；药物耐受性,1材料与方法,2结果,3讨论,参考文献：
[摘要]目的：探讨子宫颈癌多药耐药(MDR)基因产物(P_糖蛋白，P_gp)的表达及其意义。方法：采用S_P免疫组化法测定38例子宫颈癌，16例子宫颈上皮内肿瘤(CIN)和16例正常子宫颈组织的P_gp表达。结果：上述组织均有P_gp表达，子宫颈癌强阳性表达率较正常子宫颈组织高(P<005)，但与CIN比无统计学意义。P_gp强阳性表达与子宫颈癌临床分期、肿瘤分化程度以及病理组织学类型不相关。结论：子宫颈癌对抗肿瘤药物具有先天耐药性，P_gp阳性表达是子宫颈癌化疗疗效不佳的原因之一。[关键词]子宫颈肿瘤；基因表达；P_糖蛋白；药物耐受性
Expression and significance of P_glycoprotein in Cervical Carcinoma
TIAN Xue_wu，CHEN Shu_ying
(1 Department of Pathology，Changping Hospital of Dongguan, Dongguan 523573，China；2 Department of Gynecology，General Hospital of Pingdingshan Coal Group，Pingdingshan 467000，China)
[Abstract]Objective：To study the expression and significance of P_glycoprotein(P_gp)in cervical carcinoma. Me_thods：The P_gp expression of tissues in 38 cases of cervical carcinoma, 16 cases of cervical intraepithelial neoplasm(CIN)and 16 cases of normal cervix was detected by S_P immunohistochemical method. Results：The P_gp expression was found in all tissues mentioned above. The strongly positive staining in cervical carcinoma was higher than that of the normal cervix(P<005). Conclusion：There is primary multidrug resistance for cervical carcinoma, the positive expression of P_gp is one of the reasons for chemotherapy failure. ......
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