【摘要】 目的 以高血压病患者为临床观察对象，观察卡托普利对高血压病患者血压、血浆肾素-血管紧张素-醛固酮的影响，进一步探讨卡托普利的临床疗效及作用机制。方法 选取符合入选标准的病例34例，观察治疗前后患者的血压、血浆肾素-血管紧张素-醛固酮的变化。结果 治疗后降压疗效为显效21例，有效8例，无效5例，总有效率85.3%。治疗后血压有明显下降(P<0.05)，治疗后血浆PRA、AngⅡ、ALD水平有明显下降(P<0.05)。结论 卡托普利能降低和控制高血压病患者的血压，能降低血浆PRA、AngⅡ、ALD水平。其降压机制可能与其降低血浆及肾脏组织PRA、AngⅡ、ALD水平有关。

    【关键词】 卡托普利； 血压； 肾素； 血管紧张素Ⅱ； 醛固酮

    The clinical observation of the effect of captopril on hypertension and the levels of rennin, angiotensinⅡ, aldosterone in plasma

    CHEN Li-chang,LI Qi,YI Hong.

    Department of Cardiology,Huanghe Hospital,Sanmenxia City,Henan 472000,China

    【Abstract】 Objective To observe the effect of captopril lowering of blood pressure and improving clinical symptoms and rennin, angiotensin,aldosterone in plasma on hypertension patients.To explore its mechanism and the clinical effect.Methods The changes of blood pressure and rennin, angiotensin, aldosterone in plasma of 34 hypertension patients according to internaling standard were observered.Results The results of clinical observation on the effect of lowering of blood pressure made clear that there were 34 cases,among them very effect 21 cases,effect 8 cases,inefficacy 5 cases,total effective rate was 85.3%.Blood pressure was significantly decreased (P<0.05). Renin,angiotensinⅡ,aldosterone in plasma were significantly decreased (P<0.05).Conclusion The findings prompted that blood pressure of the therapy with captopril decreased; renin, angiotensinⅡ,aldosterone in plasma of the therapy with captopril decreased.So we consider its mechanism may be related with decreasing the levels of renin,angiotensinⅡ,aldosterone in plasma and kidney tissue. ......