怡诺思与阿普唑仑治疗广泛性焦虑症对照研究
怡诺思；阿普唑仑；广泛性焦虑症；汉密顿焦虑量表；焦虑自评量表；副反应量表,【摘要】,【关健词】,1对象与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨怡诺思治疗广泛性焦虑症的临床疗效和安全性。方法 将68例广泛性焦虑症患者随机分为怡诺思组34例和阿普唑仑组34例。怡诺思组治疗剂量75～150mg·d-1，阿普唑仑组为1.2～3.6mg·d-1观察时间均为6w。治疗前与治疗第1,2,4,6w末采用汉密顿焦虑量表、焦虑自评量表、副反应量表评定临床疗效和副反应。结果 两组疗效相当，差异无显著性(P>0.05)；阿普唑仑组起效时间快于怡诺思组，但远期疗效差于怡诺思组；怡诺思组副反应明显少于阿普唑仑组(P<0.05)。结论 怡诺思治疗广泛性焦虑疗效肯定，安全性高，依从性好。【关健词】 怡诺思；阿普唑仑；广泛性焦虑症；汉密顿焦虑量表；焦虑自评量表；副反应量表
A controlled study of venlafaxine and alpralid in generalized anxiety
Zhou Mengyu，Zhu Shao kuei
(The 8th People's Hospital of Zhengzhou,450000, Henan, China)
【Abstract】 Objective To explore the clinical efficacy and safety of venlafaxine in generalized anxiety. Methods 68 patients with generalized anxiety were randomly divided into venlafaxine and alpralid group (each n=34).Dosage of the venlafaxine was 75~150mg/day and the alpralid 1.2~3.6mg/day for 6 weeks. Clinical efficacy and side effects were assessed using Hamilton Anxiety Rating Scale(HAMA),the Selfrating Anxiety Scale(SAS) and the Treatment Emergent Symptom Scale(TESS) before treatment and at the ends of 1st,2nd ,4th and 6th week treatment. Results Efficacies of the 2 groups were equivalent and difference wasn't significant(P>0.05); alpralid took effect faster than venlafaxine did, but its long-term efficacy was poor; side effects of the venlafaxine was significantly fewer than those of the alpralid(P<0.05). Conclusion Venlafaxine has better efficacy, higher safety and compliance in the treatment of generalized anxiety. ......
您现在查看是摘要页，全文长 5870 字符。