齐拉西酮与氯氮平治疗难治性精神分裂症对照研究
难治性精神分裂症；齐拉西酮；氯氮平；疗效,,难治性精神分裂症；齐拉西酮；氯氮平；疗效,【摘要】,【关键词】,1对象与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨齐拉西酮治疗难治性精神分裂症的疗效及安全性。 方法 将133例难治性精神分裂症患者随机分为齐拉西酮治疗组67例，氯氮平治疗组66例，疗程均为6mo。治疗前及治疗第2、4、6mo分别采用简明精神病量表、阴性症状量表、社会功能缺损筛选量表、临床总体印象量表评定临床疗效，副反应量表评定不良反应。 结果 简明精神病量表、阴性症状量表、社会功能缺损筛选量表、临床总体印象量表评定治疗第2、4、6mo末与治疗前比较均有极显著性差异(P<0.01)，两组间比较均无显著性差异(P>0.05)；齐拉西酮主要不良反应为轻度静坐不能、震颤、头痛、恶心、嗜睡等；氯氮平为头晕、流涎、体重增加、嗜睡、恶心呕吐、心肌劳损、粒细胞减少等。齐拉西酮不良反应发生率明显低于氯氮平，且程度轻。 结论 齐拉西酮治疗难治性精神分裂症疗效与氯氮平相当，不良反应较氯氮平轻，服药依从好，可作为难治性精神分裂症的首选药物。【关键词】 难治性精神分裂症；齐拉西酮；氯氮平；疗效
A control study of ziprasidone vs clozapine in the treatment of refractory schizophrenia
Tang Buchun,Lu Zhixin, Zhou Zhenhe
(Wuxi mental health center, 214151, Jiangsu, China)
【Abstract】 Objective To explore the curative effect and safety of ziprasidone in the treatment of refractory schizophrenia. Methods 133 refractory schizophrenics were randomly divided into ziprasidone(n=67) and clozapine(n=66) group for 6 months. The curative effects were assessed with The Brief Psychiatric rating Scale(BPRS),Scale for Assessment of Negative Symptom(SANS), Social Disability Screening Schedule(SDSS) and Clinical Global Impression(CGI) and side effects with Treatment Emergent Symptom Scale(TESS) before treatment and in the 2nd,4th and 8th month of treatment, respectively. Results There were the most significant difference in the BPRS,SANS,SDSS and CGI between pretreatment and each timesection of treatment(P<0.01) and no significant difference between the 2 groups(P>0.05). The main sideeffects of ziprasidone were mild akathisia, tremble, headache, nausea, somnolence and so on; those of clozapine were dizziness, salivation, weight gain, somnolence, nausea and vomiting, involvement of myocardium, hypogranulocytosis, Incidence rate of side effects was significantly lower and milder in ziprasidone than in clozapine. Conclusion Ziprasidone has same curative effect with clozapine, milder side effects and better compliance, and could be firstselected drug in the treatment of refractory schizophrenia ......
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