【摘 要】 目的 研究罗红霉素肠溶胶囊在健康人体内的药代动力学特征。 方法 20名志愿者单剂量口服150mg的罗红霉素肠溶胶囊，采用LC-MS法测定其血清中罗红霉素浓度。 结果 罗红霉素肠溶胶囊药-时曲线符合二室开放模型，主要药代动力学参数为:T 1/2 (5.724±4.780)h、T max (3.861±1.234)h、C max (3.072±0.821)μg/ml、AUC 0～48 (48.330±16.649)μgh/ml。 结论 罗红霉素系肠溶胶囊药代动力学参数符合该剂型的特征。

    【关键词】 罗红霉素肠溶胶囊;LC-MS法;药代动力学

    The investigation of the pharmacokinetics of roxithromycin enterosoluble capsules in Chinese healthy volunteers

    HUANG Li-rong，LI Jian-chun，ZHU Xiao-guang，et al.

    (Department of Pharmacy，Affliated Hospital of Bengbu Medical College，Anhui233003，China)

    【Abstract】 Objective To investigate the pharmacokinetics of roxithromycin enterosoluble capsules in Chinese healthy volun┐teers.Methods 20male healthy subjects received a single dose of150mg roxithromycin enterosoluble capsules.The serum con-centration of roxithromycin was determined by LC-MS method.Results The main pharmacokinetic parameters of roxithromycin enterosoluble capsules were T1/2 (5.724±4.780)h ......